Efficacy,safety and biomarkers of SG001 for patients with previously treated recurrent or metastatic cervical cancer:an open-label,multicenter,phase Ib trial
摘要
Cervical cancer(CC)is one of the most common gynecological cancers,ranking fourth in incidence and mortality rates among women worldwide and second in China[1].Approximately 15%-61%of patients with CC develop recurrent or metastatic(r/m)disease in the first two years after initial therapy completion,with a 5-year survival rate of 17%[2].Platinum-based chemotherapy is the first-line treatment for r/mCC.
基金
supported by the CSPC Zhongqi Pharmaceutical Technology(Shijiazhuang)Co.,Ltd.
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1LEI LIU,NA GUO,XIANGLING LI,QIAN XU,RUILONG HE,LIMIN CHENG,CHUNYAN DANG,XINYU BAI,YIYING BAI,XIN WANG,QIANHUI CHEN,LI ZHANG.miR-125b reverses cisplatin resistance by regulating autophagy via targeting RORA/BNIP3L axis in lung adenocarcinoma[J].Oncology Research,2024,32(4):643-658.
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2Ke Gong,Jinghan Liao,Jiangtao Lin,Quan Wang,Zhihua Wu,Liting Wang,Jiali Zhang,Yi Dong,Yourong Duan,Jianhua Chen.Mitochondria-targeted nanoparticles overcome chemoresistance via downregulating BACH1/CD47 axis in ovarian carcinoma[J].Chinese Chemical Letters,2024,35(5):344-350.
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3Anqi Lin,Hong Yang,Jian Zhang,Peng Luo.CD209 signaling pathway as a biomarker for cisplatin chemotherapy response in small cell lung cancer[J].Genes & Diseases,2024,11(3):11-14.
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4高莹,桂枫,刘欣.半导体激光与Nd:YAG激光辅助牙周基础治疗对Ⅱ~Ⅲ期慢性牙周炎的效果比较[J].中国现代医药杂志,2024,26(8):40-44.
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5Anqi Lin,Weiming Mou,Lingxuan Zhu,Tao Yang,Chaozheng Zhou,Jian Zhang,Peng Luo.Mutations in the DNA polymerase binding pathway affect the immune microenvironment of patients with small-cell lung cancer and enhance the efficacy of platinum-based chemotherapy[J].Cancer Innovation,2023,2(6):500-512.
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6Yi-Long Wu,Shun Lu,Gongyan Chen,Jianxing He,Jifeng Feng,Yiping Zhang,Liyan Jiang,Hongming Pan,Jianhua Chang,Jian Fang,Amy Cai,Lilian Bu,Jane Shi,Jinjing Xia.IMpower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer[J].Chinese Journal of Cancer Research,2024,36(2):103-113.
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7Yanfang Liu,Yan Wang,Bing Liu,Wenzhong Liu,Yuanyuan Ma,Yiren Cao,Shi Yan,Panpan Zhang,Lixin Zhou,Qimin Zhan,Nan Wu.Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway[J].Science China(Life Sciences),2024,67(4):663-679.
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8J Diabetes编辑部.2024年Journal of Diabetes第8期中文导读[J].中华内分泌代谢杂志,2024,40(9):808-810.
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9Maria A.Bantounou,Josip Plascevic,Lewis MacDonald,Man Chun Wong,Neasa O'Connell,Helen F.Galley.Enfortumab vedotin and pembrolizumab as monotherapies and combination treatment in locally advanced or metastatic urothelial carcinoma:A narrative review[J].Current Urology,2023(4):271-279.
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