摘要
刺激响应性和可生物降解性天然聚合物基水凝胶是药物缓释载体研究的重要发展方向。基于此开发了基于普鲁兰多糖(Pullulan)的p H/氧化还原响应水凝胶。以Pullulan为基体,以甲基丙烯酸二甲氨乙酯(DMAEMA)和丙烯酸(AA)为p H响应性单体,以具有N, N'-双(丙烯酰)胱胺(BAC)为交联剂,制备具有p H/氧化还原响应性的水凝胶(PPAD),通过调控p H值和溶胀-收缩机制来控制OMT缓慢释放。载药水凝胶在p H=1.5、p H=6.8和p H=7.4时,对氧化苦参碱(OMT)的累计释放量分别为66.7%、40.0%和35.2%。PPAD1~6在p H=1.5的累计释放量分别为60.34%、66.7%、74.0%、73.0%、63.5%、54.6%,氧化还原降解实验验证了PPAD的氧化还原性。
Stimuli-responsive and biodegradable natural polymer-based hydrogels are an important development in the study of slow-release carriers for drugs.Based on this pH/redox responsive hydrogels based on Pullulan polysaccharide(Pullulan)were developed.Pullulan as matrix,dimethylaminoethyl methacrylate(DMAEMA)and acrylic acid(AA)as pH-responsive monomers,and redox-responsive BAC as cross-linking agent were used to prepare pH/redoxresponsive hydrogels(PPADs),which were used to control the slow release of OMT by modulating the pH and the swelling-contraction mechanism.The cumulative release of OMT from the drug-loaded hydrogels was 66.7%,40.0%,and 35.2%at pH=1.5,pH=6.8,and pH=7.4,respectively.the cumulative release of PPAD1 to 6 at pH=1.5 was 60.34%,66.7%,74.0%,73.0%,63.5%,and 54.6%,respectively.
作者
马文浩
刘汉达
段秀红
尚宏周
张雪鹏
Ma Wen-hao;Liu Han-da;Duan Xiu-hong;Shang Hong-zhou;Zhang Xue-peng(College of Materials Science and Engineering,North China University of Science and Technology,Tangshan Hebei 063210,China;College of Pharmacy,North China University of Science and Technology,Tangshan Hebei 063210,China;Affiliated Hospital of North China University of Science and Technology,Tangshan Hebei 063000,China)
出处
《华北理工大学学报（自然科学版）》
CAS
2024年第4期35-44,共10页
Journal of North China University of Science and Technology：Natural Science Edition
基金
河北省高等学校科学技术研究项目(QN2023123):基于聚噻吩衍生物的生物硫醇荧光探针的设计及应用研究
华北理工大学重点科研项目(ZD-YG-202408):具有刺激响应和光热转换性能的核壳型药物缓释系统构建及其协同治疗乳腺癌细胞效果评价。
关键词
普鲁兰多糖
水凝胶
刺激响应
氧化苦参碱
药物递送
Pullulan polysaccharide
Hydrogel
stimulus response
Oxidized Bittersweet
drug delivery
