摘要
目的:基于孟德尔随机化分析(MR)方法从基因遗传角度探讨骨质疏松症(OP)患病率与骨关节炎(OA)患病率之间的关联性。方法:以单核苷酸多态性位点(SNPs)作为工具变量来分析暴露因素和结局因素之间潜在的因果关系。采用MR方法分析OP与OA在患病率方面的因果效应关系。使用逆方差加权法、MR-Egger回归、加权中位数法来计算OP与OA在患病率方面的因果关联。结果:当骨密度水平(BMD)作为暴露数据集、OA作为结局数据时,BMD水平与OA之间呈现正向因果效应(OR=1.00,95%CI:1.00~1.01,P=2.00×10^(-4)<0.01)。当OA作为暴露数据集、BMD水平作为结局数据时,两者之间呈现负向因果效应(OR<1.00,P<0.01)。不同部位BMD水平、OA的MR分析结果显示:在正向的MR分析中,只有前臂骨密度水平(FA-BMD)作为暴露数据集、膝关节炎(KOA)作为结局数据集时,BMD水平与OA之间呈现负向因果效应(OR=1.14,95%CI:1.08~1.19,P<0.01);在反向的MR分析中,二者之间没有统计学关联(OR=1.14,95%CI:1.08~1.19,P>0.05),OA与OP的关系受发病部位影响。结论:BMD水平升高可能会增加OA的患病风险,OP与OA在患病率方面可能呈负相关关系,即OP患者发生OA的概率较低。
Objective:To analyze the correlation between the prevalence of osteoporosis(OP)and osteoarthritis(OA)from the genetic perspective based on Mendelian randomization analysis(MR).Methods:Single nucleotide polymorphism sites(SNPs)were used as instrumental variables to analyze potential causal relationships between exposure factors and outcome factors.The causal relationship between OP and OA in morbidity was analyzed by MR Method.Inverse variance weighting,MR-Egger regression and weighted median method were used to calculate the causal association between OP and OA in terms of morbidity.Results:When bone mineral density(BMD)level was used as exposure dataset and OA as outcome dataset,there was a positive causal effect between BMD level and OA(OR=1.00,95%CI:1.00-1.01,P=2.00×10^(-4)<0.01).When OA was used as exposure dataset and BMD level as outcome dataset,there was a negative causal effect between them(OR<1.00,P<0.01).MR analysis results of BMD level and OA in different parts showed:In the positive MR analysis,only when forearm bone density level(FA-BMD)was used as exposure dataset and knee arthritis(KOA)as outcome dataset,there was a negative causal effect between BMD level and OA(OR=1.14,95%CI:1.08-1.19,P<0.01);In reverse MR analysis,there was no statistical correlation between OA and OP(OR=1.14,95%CI:1.08-1.19,P>0.05);The relationship between OA and OP was affected by the site of disease.Conclusion:Elevated BMD level may increase the risk of OA.There may be a negative correlation between OP and OA in terms of incidence,meaning that OP patients have a lower probability of developing OA.
作者
赵碧仪
孙伟鹏
林青
钟文强
朱晓峰
张荣华
ZHAO Biyi;SUN Weipeng;LIN Qing;ZHONG Wenqiang;ZHU Xiaofeng;ZHANG Ronghua(College of Traditional Chinese Medicine,Jinan University,Guangzhou 510632,Guangdong,China;College of Pharmacy,Jinan University,Guangzhou 510632,Guangdong,China;Guangdong Key Laboratory of Traditional Chinese Medicine Informatization,Guangzhou 510632,Guangdong,China)
出处
《暨南大学学报（自然科学与医学版）》
CAS
北大核心
2024年第4期366-377,共12页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
国家重点研发计划项目(2018YFC2002500)
国家自然科学基金面上项目(82074287,82274232)
广东省科技计划项目-广东省中医药信息化重点实验室(2021B1212040007)
广东省基础与应用基础研究基金区域联合基金项目(2022B1515120022)
张荣华广东省名中医传承工作室建设项目(粤中医办函[2023]108号)。
关键词
骨质疏松症
骨关节炎
骨密度
孟德尔随机化
osteoporosis
osteoarthritis
bone mineral density
Mendelian randomization
