摘要
目的:观察扶正护骨汤联合椎体后凸成形术治疗老年骨质疏松性胸腰椎骨折的临床效果。方法:采用随机数字表法将100例老年骨质疏松性胸腰椎骨折患者分为对照组、观察组各50例。对照组给予微创手术椎体后凸成形术治疗,观察组予微创手术椎体后凸成形术联合扶正护骨汤治疗。比较2组治疗前、治疗1个月、3个月后视觉模拟评分法(VAS)评分、中医证候积分、Oswestry功能障碍评分、腰椎骨密度及骨代谢指标(25羟维生素D、N-端骨钙素,β-胶原特殊序列,总Ⅰ型胶原氨基端延长肽)水平,并随访统计2组术后再骨折发生率。结果:治疗1个月、3个月后,2组VAS评分、中医证候积分、Oswestry功能障碍评分均较治疗前降低(P<0.05),观察组VAS评分、中医证候积分、Oswestry功能障碍评分低于对照组(P<0.05)。治疗1个月、3个月后,2组25羟维生素D、N-端骨钙素水平较治疗前升高(P<0.05),β-胶原特殊序列,总Ⅰ型胶原氨基端延长肽水平降低(P<0.05);观察组25羟维生素D、N-端骨钙素水平高于对照组(P<0.05),β-胶原特殊序列、总Ⅰ型胶原氨基端延长肽水平低于对照组(P<0.05)。2组治疗3个月后腰椎骨密度较治疗前升高(P<0.05),且观察组腰椎骨密度高于对照组(P<0.05)。观察组术后再骨折发生率2.00%,低于对照组12.00%(P<0.05)。结论:扶正护骨汤联合椎体后凸成形术治疗老年骨质疏松性胸腰椎骨折,能够缓解患者疼痛症状,调节骨代谢,提升骨密度,降低术后再骨折发生率。
Objective:To observe the clinical effect of Fuzheng Hugu Decoction combined with kyphoplasty on osteoporotic thoracolumbar fractures in the elderly.Methods:A total of 100 cases of elderly patients with osteoporotic thoracolumbar fractures were divided into the control group and the observation group according to the random number table method,with 50 cases in each group.The control group received minimally invasive surgery of kyphoplasty,and the observation group was treated with minimally invasive surgery of kyphoplasty and Fuzheng Hugu Decoction.The Visual Analogue Scale(VAS)scores,traditional Chinese medicine syndrome scores,Oswestry Disability Index,and the levels of lumbar spine bone density and bone metabolism indicators(25 hydroxyvitamin D,N-terminal osteocalcin,β-collagen special sequence,and total procollagen typeⅠN-terminal propeptide)were compared between the two groups before treatment and after one and three months of treatment.Results:After one and three months of treatment,VAS scores,traditional Chinese medicine syndrome scores,and scores of Oswestry Disability Index in the two groups were declined when compared with those before treatment(P<0.05),and VAS scores,traditional Chinese medicine syndrome scores,and scores of Oswestry Disability Index in the observation group were lower than those in the control group(P<0.05).After one and three months of treatment,the levels of 25 hydroxyvitamin D and N-terminal osteocalcin in the two groups were increased when compared with those before treatment(P<0.05),and the levels ofβ-collagen special sequence and total procollagen typeⅠN-terminal propeptide were reduced(P<0.05);the levels of 25 hydroxyvitamin D and N-terminal osteocalcin in the observation group were higher than those in the control group(P<0.05),and the levels ofβ-collagen special sequence and total procollagen typeⅠN-terminal propeptide in the observation group were lower than those in the control group(P<0.05).After three months of treatment,lumbar bone mineral density in the two grou
作者
邓红平
吴恙
吴苏柳
吴杭钦
董阳昕
DENG Hongping;WU Yang;WU Suliu;WU Hangqin;DONG Yangxin(The Second Department of Orthopedics,Wuyi County First People's Hospital,Wuyi Zhejiang 321200,China;Department of Orthopedics,Jinhua Municipal Central Hospital,Jinhua Zhejiang 321000,China;Department of Chinese Medicine,Wuyi County First People's Hospital,Wuyi Zhejiang 321200,China)
出处
《新中医》
CAS
2024年第20期75-79,共5页
New Chinese Medicine
基金
金华市中医药科学技术研究计划项目(2022KY61)。
关键词
骨质疏松性胸腰椎骨折
老年
椎体后凸成形术
扶正护骨汤
骨密度
骨代谢
Osteoporotic thoracolumbar fractures
Elderly
Kyphoplasty
Fuzheng Hugu Decoction
Bone mineral density
Bone metabolism
