摘要
在后cART时代,随着HIV/AIDS患者生存期的延长,其发生非艾滋病定义性疾病(NAD)的风险出现上升趋势,其中代谢综合征(MS)严重影响了HIV/AIDS患者的生存质量及预后。受到HIV相关因素、社会人口学和行为因素的影响,HIV/AIDS患者更易发生MS,但MS的疾病组成复杂,目前HIV/AIDS患者MS的发病机制未明,其流行情况、影响因素及临床特征等在不同地区的相关研究中存在较大差异。本文通过对HIV/AIDS患者MS的流行情况、发病机制、临床特征、影响因素等进行综述,以期为HIV/AIDS患者MS早期诊断及个体化治疗的研究提供思路和方向。
In the era following the introduction of combination antiretroviral therapy(cART),HIV infected individuals are experiencing longer lifespans.Alongside these extended lifespans,there is an increased risk of non-AIDSdefining illnesses(NAD),notably metabolic syndrome(MS),which severely affects the quality of life and prognosis.MS in individuals with HIV/AIDS is influenced by a complex interplay of factors related to HIV,sociodemographic characteristics,and behavioral patterns,making these individuals particularly vulnerable to developing MS.The pathophysiology of MS is complex and its underlying mechanisms in the HIV/AIDS population are not fully understood.Additionally,research into the epidemiological aspects,determinants,and clinical features of MS shows significant variability across different regions.This review consolidates current epidemiological trends,pathogenic mechanisms,clinical characteristics,and contributing factors of MS in HIV/AIDS patients.It aimed to support further research into early diagnostic methods and customized therapeutic strategies for managing MS in this population.
作者
戴璐
宋玉霞
邓江玲
DAI Lu;SONG Yuxia;DENG Jiangling(The Eighth Clinical Medical School,Xinjiang Medical University,Urumqi,830013,Xinjiang Uygur Autonomous Region,China)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2024年第9期988-992,共5页
Chinese Journal of Aids & STD
基金
新疆维吾尔自治区自然科学基金面上项目(2021D01A128)。
