摘要
目的评价含有杏仁酸及烟酰胺的护肤品辅助治疗轻、中度痤疮的疗效及安全性。方法前瞻性纳入2020年6-10月空军军医大学西京医院50例轻中度痤疮患者,采用随机数字表法将患者分为观察组和对照组,每组25例。其中观察组男3例,女22例,年龄(22.5±3.2)岁;对照组男3例,女22例,年龄(22.9±2.8)岁。对照组按照痤疮常规治疗方法进行治疗,期间除日常洁面,不做其他护肤;观察组在常规治疗基础上使用含有杏仁酸及烟酰胺的护肤品。分别于治疗后2、4、8周采用皮肤性质测试仪(CK)及皮肤图像分析仪(VISIA)对两组患者皮损个数、皮肤屏障功能恢复状况进行客观评价,并由患者填写不良反应记录表。结果两组患者性别、年龄、病程及病情严重程度差异均无统计学意义(均P>0.05),具有可比性。所有患者均完成相关治疗,治疗8周后,观察组皮损改善有效率、粉刺改善有效率分别为84.0%(21/25)、84.0%(21/25),对照组皮损改善有效率、粉刺改善有效率分别为56.0%(14/25)、44.0%(11/25);与对照组比较,观察组皮损改善有效率、粉刺改善有效率均升高(均P<0.001)。VISIA结果显示,相较于对照组,观察组患者治疗8周后毛孔、紫质分值降低(P=0.035、0.027)。CK结果显示,相较于对照组,观察组经皮水分丢失量减少,皮肤油脂含量降低(P=0.009、0.042)。共5例患者出现皮肤红斑、干燥、烧灼或瘙痒,其中观察组3例,对照组2例。两组患者均未发生严重不良反应。结论含有杏仁酸及烟酰胺的护肤品可用于辅助治疗轻中度痤疮,增加其临床疗效,且不良反应少。
ObjectiveTo assess the efficacy and safety of skin care products containing mandelic acid and niacinamide in the management of mild to moderate acne.MethodsA total of 50 patients with mild to moderate acne were prospectively enrolled at Xijing Hospital,Air Force Military Medical University,from June to October 2020.Participants were randomly assigned into an observation group and a control group using a random number table method,with each group comprising 25 individuals.The observation group consisted of 3 males and 22 females,with a mean age of(22.5±3.2)years;the control group also included 3 males and 22 females,with a mean age of(22.9±2.8)years.The control group received conventional acne treatment without any additional skin care interventions apart from daily facial cleaning;conversely,the observation group was treated with skin care products containing mandelic acid and niacinamide alongside standard treatment protocols.At weeks 2,4,and 8 post-treatment,objective assessments utilizing skin property system and VISIA complexion analysis system were conducted to evaluate changes in lesion count as well as recovery of skin barrier function between both groups;additionally,patients completed adverse reaction record forms.ResultsNo significant differences were observed regarding gender distribution,age demographics,disease duration or severity between the two groups(P>0.05).After 8 weeks of treatment,the rates of effective improvement for skin lesions and acne were observed to be 84.0%(21/25)in the observation group compared to 56.0%(14/25)in the control group for lesion improvement,and 84.0%(21/25)versus 44.0%(11/25)for acne improvement,respectively.When compared to the control group,the observation group demonstrated significantly higher rates of effective improvement in both skin lesions and acne(P<0.001).VISIA analysis revealed that pore size scores as well as violet scores decreased significantly after eight weeks in comparison to controls(P=0.035;P=0.027).CK results indicated reduced transepidermal water
作者
张倩
王媛丽
景焕
李凯
Zhang Qian;Wang Yuanli;Jing Huan;Li Kai(Department of Dermatology,Xijing Hospital,Air Force Military Medical University,Xi'an 710032,China)
出处
《中华医学美学美容杂志》
2024年第5期494-500,共7页
Chinese Journal of Medical Aesthetics and Cosmetology
关键词
痤疮
寻常
杏仁酸
烟酰胺
皮肤屏障功能
不良反应
Acne vulgaris
Mandelic acid
Niacinamide
Skin barrier function
Adverse reaction
