摘要
目的:研究探讨急性冠状动脉综合征(ACS)患者内质网应激相关蛋白(CHOP)、软骨寡聚基质蛋白(COMP)、腱糖蛋白C(TN-C)与冠状动脉病变程度和经皮冠脉介入术(PCI)术后主要心血管不良事件(MACE)的关系。方法:选取2020年9月~2022年9月我院收治的175例ACS患者为对象纳入观察组,另选同期本院进行体检的健康受试者50例纳入对照组。检测对比两组CHOP、COMP、TN-C水平,并将ACS患者根据病情程度分为轻度、中度、重度组,对比不同病情程度各项指标水平。患者均进行PCI手术治疗,进行术后1年随访,统计MACE发生率,对比MACE组和非MACE组的血清CHOP、COMP、TN-C水平。采用单因素和多因素Logistic回归模型分析ACS患者PCI术后MACE与血清CHOP、COMP、TN-C的关系。结果:观察组血清CHOP、COMP、TN-C水平高于对照组(P<0.05)。重度组ACS患者血清CHOP、COMP、TN-C水平高于中度组且高于轻度组(P<0.05)。术后1年,MACE发生率为23.43%(41/175),MACE组血清CHOP、COMP、TN-C水平高于非MACE组患者(P<0.05)。经单因素分析,MACE组患者美国纽约心脏病学会(NYHA)心功能分级Ⅲ-Ⅳ级、高血压病史、糖尿病史、高脂血症比例高于非MACE组(P<0.05)。经Logistic多因素分析,CHOP、COMP、TN-C水平高及NYHA心功能分级Ⅲ-Ⅳ级、高血压病史、糖尿病史、高脂血症是ACS患者PCI术后MACE发生的独立危险因素。结论:血清CHOP、COMP、TN-C在ACS患者中呈现升高表达,并随患者病情程度加重而进一步升高,且与NYHA心功能分级、合并基础疾病一起构成ACS患者PCI术后MACE发生的独立危险因素。
Objective:To investigate the relationship between endoplasmic reticulum stress-related protein(CHOP),cartilage oligomeric matrix protein(COMP),tendone protein-C(TN-C)and the severity of coronary artery disease and major adverse cardiovascular events(MACE)after percutaneous coronary intervention(PCI)in patients with acute coronary syndrome(ACS).Methods:175 ACS patients admitted to our hospital from September 2020 to September 2022 were selected as observation group,and 50 healthy subjects who underwent physical examination in our hospital during the same period were selected as control group.The levels of CHOP,COMP and TN-C were detected and compared between two groups,and ACS patients were divided into mild,moderate and severe groups according to the severity of the disease,and the levels of various indicators were compared.All patients were treated with PCI,and followed up for 1 year after operation,the incidence of MACE was counted,and the levels of serum CHOP,COMP and TN-C in MACE group and non-MACE group were compared.The relationship between MACE and serum CHOP,COMP and TN-C in ACS patients after PCI were analyzed by univariate and multivariate Logistic regression models.Results:The levels of serum CHOP,COMP and TN-C in observation group were higher than those in control group(P<0.05).The levels of serum CHOP,COMP and TN-C in severe group were higher than those in moderate group and higher than those in mild group(P<0.05).1 year after operation,the incidence of MACE was 23.43%(41/175),the levels of serum CHOP,COMP and TN-C in MACE group were higher than those in non-MACE group(P<0.05).By univariate analysis,the proportion of patients with New York Heart Association(NYHA)cardiac function gradeⅢ-Ⅳ,history of hypertension,history of diabetes and hyperlipidemia in MACE group was higher than that in non-MACE group(P<0.05).Logistic multivariate analysis showed that,high levels of CHOP,COMP,TN-C,NYHA cardiac function gradeⅢ-Ⅳ,history of hypertension,history of diabetes and hyperlipidemia were independent ri
作者
赵柄烨
连俊
程晋芳
刘晋文
张志军
ZHAO Bing-ye;LIAN Jun;CHENG Jin-fang;LIU Jin-wen;ZHANG Zhi-jun(Department of Internal Medicine-Cardiovascular,Shanxi Academy of Medical Sciences/Shanxi Norman Bethune Hospital,Taiyuan,Shanxi,030000,China)
出处
《现代生物医学进展》
CAS
2024年第18期3465-3469,3414,共6页
Progress in Modern Biomedicine
基金
山西省基础研究计划项目(202303021211222)。
