摘要
目的探讨地诺孕素治疗复发性卵巢子宫内膜异位囊肿(OEM)的临床效果。方法选取2022年2月至2023年8月威海市妇幼保健院收治的86例复发性OEM患者作为研究对象,以随机数字表法分为研究组(n=43)与对照组(n=43)。对照组给予常规治疗,研究组给予地诺孕素治疗。比较两组囊肿体积、激素水平、卵巢储备功能、血流动力学及不良反应发生情况。结果治疗后,两组囊肿体积均缩小,且研究组较对照组更小(P<0.05)。治疗后,两组雌二醇、卵泡刺激素水平均下降,且研究组水平较对照组更低(P<0.05)。治疗后,两组抗米勒管激素水平均下降,且研究组水平较对照组更低(P<0.05)。治疗后,两组窦卵泡计数比较,差异无统计学意义(P>0.05)。治疗后,两组卵巢动脉血流搏动指数、阻力指数均下降,且研究组较对照组更低(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论地诺孕素治疗复发性OEM可缩小囊肿体积,改善激素水平、卵巢储备功能、血流动力学,且不增加不良反应。
Objective To explore the clinical effect of Dienogest in the treatment of recurrent ovarian endometriotic cysts(OEM).Methods A total of 86 patients with recurrent OEM who were admitted to Weihai Maternal and Child Health Hospital from February 2022 to August 2023 were selected as the study objects.All the patients were divided into the study group(n=43)and the control group(n=43)by the random number table method.The control group received routine treatment,and the study group received the treatment with Dienogest.The cyst volume,hormone levels,ovarian reserve function,hemodynamics,and incidence of adverse reactions of the two groups were compared.Results After treatment,the cyst volume in both groups was decreased,and that of the study group was smaller than that of the control group(P<0.05).After treatment,the estradiol and follicle stimulating hormone levels in both groups were decreased,and the levels of the study group were lower than those of the control group(P<0.05).After treatment,the anti-Müllerian hormone levels in both groups were decreased,and the level of the study group was lower than that of the control group(P<0.05).After treatment,there was no statistically significant difference in antral follicle count between the two groups(P>0.05).After treatment,the ovarian arterial blood flow pulsation index and resistance index in both groups were decreased,and those of the study group were lower than those of the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Deinorgestrel for treatment of recurrent OEM can reduce cyst volume,improve hormone levels,ovarian reserve function,hemodynamics,and does not increase adverse reactions.
作者
刘倩倩
张雪蕾
LIU Qianqian;ZHANG Xuelei(Department of Gynecology and Obstetrics,Weihai Maternal and Child Health Hospital,Shandong Province,Weihai 264200,China)
出处
《妇儿健康导刊》
2024年第19期95-98,138,共5页
JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE
