摘要
胰岛素样生长因子(IGFs)信号系统是调节机体生长、发育和衰老的关键途径之一。IGFs的信号转导受胰岛素样生长因子结合蛋白(IGFBPs)的调节。IGFBP5,作为IGFBPs家族中的一员,有该家族成员中跨物种最保守的序列,却具有最多样的生物学作用。IGFBP5的表达水平及功能作用在不同背景下可能不同。多项研究结果显示,IGFBP5水平的升高可能会降低机体的生殖能力。然而,关于IGFBP5升高对糖脂代谢紊乱及糖尿病并发症发生的影响,目前的研究结果仍存在较多矛盾。总之,IGFBP5是一种多功能蛋白,它的作用效果及作用机制有很强的背景特异性,其能够在特定的空间和时间内,通过不同的途径,发挥着正向或负向的调节作用。
The insulin-like growth factors(IGFs)signaling system is one of the key pathways that regulating the growth,development,and aging of the body.The signaling of IGFs is regulated by the insulin-like growth factor-binding proteins(IGFBPs).IGFBP5,as a member of the IGFBPs family,has the most conserved sequences among the members of the IGFBPs family across species yet,and which has the most diverse biological roles.The expression level and the functional role of IGFBP5 may differ in the different contexts.The results of several previous studies show that the elevated level of IGFBP5 may reduce the reproductive capacity of the body.However,the results of the current studies on the influence of the elevated IGFBP5 level of the body on their disorders of glucose-lipid metabolism and their development of diabetic complications are all still highly contradictory.In conclusion,IGFBP5 is a multifunctional protein with the strong background specificity in its effect and mechanism of action,which is capable of the exerting positive or negative regulatory effect in a specific space and time,through different pathways.
作者
尹倩倩
郑建华
严晓南
曹义娟
YIN Qianqian;ZHENG Jianhua;YAN Xiaonan;CAO Yijuan(Xuzhou Central Hospital,Xuzhou,Jiangsu Province,221009;Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy,Xuzhou Medical University,Xuzhou)
出处
《中国计划生育学杂志》
2024年第10期2459-2463,共5页
Chinese Journal of Family Planning
基金
江苏省卫生健康委科研项目(Z2023081)
江苏省新药研究与临床药学重点实验室开放资助项目(XZSYSKF2023012)
江苏省妇幼保健协会科研项目(FYX202322)
徐州医科大学附属医院科技发展基金(XYFY202205)
国家自然科学基金(81571405)。
关键词
胰岛素样生长因子结合蛋白5
生育力
糖脂代谢
Insulin-like growth factor binding proteins
Fertility
Glucose and lipid metabolism
