摘要
目的 探讨T2DM患者血清25羟维生素D[25(OH)D]水平与DKD的相关性。方法 选取2019年5月至2021年5月于嘉善县第二人民医院内分泌科治疗的T2DM患者174例,根据UACR分为<30 mg/g正常白蛋白尿组(NUAlb,n=71)、30~300 mg/g微量白蛋白尿组(MUAlb,n=85)和≥300 mg/g大量白蛋白尿组(LUAlb,n=18),分析各组25(OH)D变化及其与UACR的相关性。结果 NUAlb、MUAlb、LUAlb组年龄、DM病程、ACEI或ARBs使用占比、SBP、DBP、FPG、SUA、25(OH)D<30 nmol/L、UACR依次升高(P<0.05)。Spearman相关分析显示,T2DM患者UACR与性别、年龄、DM病程、BMI、SBP、DBP、FPG、Hb A1c、TG、血尿酸(SUA)呈正相关(P<0.05),与HDL-C、25(OH)D呈负相关(P<0.05)。Logistic回归分析显示,性别、SBP、Hb A1c、SUA及25(OH)D是T2DM患者白蛋白尿的影响因素。结论 T2DM患者存在25(OH)D不足,以DKD患者尤为明显,25(OH)D缺乏与蛋白尿发生密切相关,是T2DM患者发生DKD的影响因素。
Objective To investigate the correlation between serum 25‐hydroxyvitamin D[25(OH)D]level and diabetic kidney disease(DKD)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 174 T2DM patients admitted to Jiashan County Second People’s Hospital from May 2019 to May 2021 were selected and divided into normal albuminuria(NUAlb)group(<30 mg/g,n=71),microalbuminuria(MUAlb)group(30~300 mg/g,n=85)and large albuminuria(LUAlb)group(≥300 mg/g,n=18)according to the urine albumin‐creatinine ratio(UACR)level.The levels of 25(OH)D in each group and its relationship with UACR were analyzed.Results The age,DM duration,use of ACEI or ARBs,SBP,DBP,FPG,SUA,proportion of 25(OH)D<30 nmol/L and UACR in NUAlb,MUAlb,LUAlb graup increased in turn(P<0.05).Spearman correlation analysis showed that UACR in T2DM patients was positively correlated with gender,age,DM duration,BMI,SBP,DBP,FPG,HbA1c,TG,and SUA(P<0.05),and negatively correlated with HDL‐C and 25(OH)D(P<0.05).Logistic regression analysis showed that gender,SBP,HbA1c,SUA,and 25(OH)D were influencing factors for albuminuria in T2DM patients.Conclusions T2DM patients have 25(OH)D shortage,especially in DKD patients.25(OH)D deficiency is closely related to proteinuria in T2DM patients.
作者
言姣
许勤俭
张俊伟
孟琪芳
YAN Jiao;XU Qinjian;ZHANG Junwei(Department of Endocrinology,Jiashan County Second People’s Hospital,Jiashan 314100,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2024年第9期667-670,共4页
Chinese Journal of Diabetes
基金
2020年嘉善县科技计划项目(2020A46)。
关键词
糖尿病
2型
25羟维生素D
糖尿病肾脏疾病
Diabetes mellitus,type 2
25‐hydroxyvitamin D
Diabetic kidney disease
