摘要
侵袭性真菌病(IFD)是一种深部感染性疾病,在血液系统恶性肿瘤患者中的发病率总体呈上升趋势。三唑类、多烯类、棘白菌素类抗真菌药物以及5-氟胞嘧啶和复方磺胺甲噁唑是临床治疗IFD的主要药物。对这些药物开展治疗药物监测有助于保证药物疗效、减少不良反应的发生。本文系统概述了以上5类药物的有效血药浓度范围,以及血药浓度与疗效和不良反应之间的相关性。固相萃取联合超高效液相色谱串联质谱技术在该研究领域是一种较有前景的检测方法。
Invasive fungal disease(IFD)is a deep infectious disease with an overall increasing incidence in patients with hematologic malignancies.Triazoles,polyenes,echinocandins echinocandin antifungal drugs,5-fluorocytosine and Compound sulfamethoxazole are the main drugs used in the clinical treatment of IFD.Therapeutic drug monitoring for IFD prevention and treatment is helpful to optimize treatment outcomes and reduce adverse effects.In this paper,the effective plasma concentration ranges of the above 5 types of drugs are systematically summarized,and the correlation between the plasma concentration of antifungal drugs and the efficacy and adverse reactions is reviewed.Solid phase extraction combined with ultra-performance chromatography-tandem mass spectrometry is a promising detection method in this research field.
作者
陈钰婷
武正华
范国荣
CHEN Yuting;WU Zhenghua;FAN Guorong(School of Medicine,Shanghai University,Shanghai 200444,China;Dept.of Clinical Pharmacy,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)
出处
《中国药房》
CAS
北大核心
2024年第20期2565-2570,共6页
China Pharmacy
基金
国家自然科学基金项目(No.81973289)。
关键词
造血干细胞移植
血液系统恶性肿瘤
侵袭性真菌病
治疗药物监测
检测方法
hematopoietic stem cell transplantation
hematologic malignancies
invasive fungal disease
therapeutic drug monitoring
analytical methods
