摘要
目的探究宫颈鳞癌中高危型人乳头瘤病毒(HPV)感染与人表皮生长因子受体-2(Her-2)、第十号染色体缺失的磷酸酶张力蛋白同源物基因(PTEN)表达的相关性。方法采取分层随机分组方法取2018年8月至2021年7月期间的高危型HPV感染的宫颈鳞癌根治标本50例宫颈鳞癌患者为A组,同时期的高危型HPV感染的宫颈活检标本40例宫颈上皮内病变患者为B组,非高危型HPV感染的宫颈活检标本30名健康同龄者为C组。检测及比较A组与B组的病变组织及C组的正常上皮组织Her-2及PTEN表达结果及高危型HPV感染率,并比较其在A组中的不同年龄、肿瘤直径、国际妇产科联盟(FIGO)分期、组织学分级、宫颈间质浸润深度、有无脉管内癌栓、有无神经束侵犯及淋巴结转移者的检测结果,采用Spearman分析法进行处理和分析宫颈鳞癌中高危型HPV感染与Her-2、PTEN表达的相关性。结果A组中Her-2阳性表达率及高危型HPV感染率高于B组及C组、B组高于C组(P<0.05);A组的组织PTEN阳性表达率低于B组及C组,B组低于C组(P<0.05)。Ⅰ~Ⅱ期Her-2、PTEN阳性表达率及高危型HPV感染率高于Ⅲ期、G1~G2级Her-2、PTEN阳性表达率及高危型HPV感染率高于G3级、有淋巴结转移者Her-2及PTEN表达结果及高危型HPV感染率低于无淋巴结转移者(P<0.05)。宫颈鳞癌中高危型HPV感染与Her-2表达呈正相关,与PTEN表达呈负相关(P<0.05)。结论宫颈鳞癌中高危型HPV感染、Her-2和PTEN的阳性表达存在异常,且三者之间关系密切,宫颈鳞癌中HER-2高表达,PTEN低表达,高危型HPV感染与Her-2表达呈正相关、与PTEN表达呈负相关,三者在宫颈病变患者中有较高的检测价值。
Objective To investigate the correlation between high-risk HPV infection and the expression of Her-2 and PTEN in cervical squamous cell carcinoma.Methods A random number table method was used to select 50 cervical squamous cell carcinoma patients with high-risk HPV infection who underwent radical treatment between August 2018 and July 2021 as Group A,40 cervical intraepithelial lesion patients with high-risk HPV infection who underwent cervical biopsy during the same period as Group B,and 30 healthy cervical biopsy samples of the same age who did not undergo high-risk HPV infection as Group C.Detect and compare the expression results of Her-2 and PTEN in the diseased tissues of Group A and Group B,as well as the normal epithelial tissues of Group C,and compare the high-risk HPV infection rate.Compare the detection results of different ages,tumor diameters,FIGO stages,histological grades,depth of cervical stromal infiltration,presence of intravascular cancer emboli,invasion of nerve bundles,and lymph node metastasis in Group A.Use Spearman analysis to process and analyze the correlation between high-risk HPV infection and Her-2 and PTEN expression in cervical squamous cell carcinoma.Results The positive expression rate of Her-2 and the infection rate of high-risk HPV in Group A were significantly higher than those in Group B and Group C,while Group B was higher than Group C(P<0.05);The positive expression rate of PTEN in tissues of Group A was significantly lower than that of Group B,while Group C and Group B were significantly lower than Group C,with statistical significance(P<0.05).The positive expression rates of Her-2 and PTEN in stagesⅠtoⅡ,as well as the infection rates of high-risk HPV,were higher than those in stageⅢ,G1 to G2 grade Her-2,PTEN positive expression rates and high-risk HPV infection rates were higher than those in G3 grade,and the expression results of Her-2 and PTEN in patients with lymph node metastasis were lower than those without lymph node metastasis,with statistical significa
作者
陈冬莲
王茜
CHEN Donglian;WANG Xi(Department of Pathology,Ganzhou Maternal and Child Health Hospital,Ganzhou 341000,China)
出处
《中国医药指南》
2024年第29期44-47,共4页
Guide of China Medicine
基金
赣州市科技计划项目(GZ2021ZSF295)。
关键词
宫颈鳞癌
高危型HPV感染
人表皮生长因子受体-2
Cervical squamous cell carcinoma
High-risk HPV infection
Human epidermalgrowth factor receptor-2
