摘要
目的:观察补肾泄浊方联合血液透析对改善慢性肾衰竭(CRF)肾功能的影响及安全性。方法:选取2021年1月—2022年5月许昌市立医院收治的112例CRF患者作为研究对象,基于随机数表法将患者分为透析组(56例)和联合组(56例),透析组予以常规血液透析治疗,联合组采用补肾泄浊方联合血液透析治疗,所有患者治疗后开展为期半年随访。比较两组患者治疗前后的免疫功能、肾功能指标变化情况,及治疗后不良事件发生情况。结果:治疗后,联合组的总T细胞(CD3^(+))、T淋巴细胞亚群4 (CD4^(+)),高于透析组,T淋巴细胞亚群8 (CD8^(+))低于透析组,差异有统计学意义(t=3.571、3.169、4.098,P<0.05);治疗后,联合组血尿素氮(BUN)、血清肌酐(SCr)、血尿酸(UA)均低于透析组,差异有统计学意义(t=3.291、3.650、3.617,P<0.05);治疗后,联合组的内生肌酐清除率(CCr)、肾小球滤过率(GFR)均高于透析组,差异有统计学意义(t=3.731、3.725,P<0.05);随访期间,联合组的不良事件发生率为10.71%,略高于透析组的8.93%,差异无统计学意义(χ^(2)=0.179,P>0.05)。结论:补肾泄浊方联合血液透析治疗CRF能增强患者免疫力并促进肾功能恢复,此中医疗法未明显增加患者不良事件发生风险,安全性较高。
Objective:To observe the effect and safety of Bushen Jiezhuo Formula combined with hemodialysis on the improvement of CRF renal function.Methods:112 patients with CRF admitted to Xuchang Municipal Hospital from January 2021 to May 2022 were selected as the study objects.Based on random number table method,the enrolled patients were divided into dialysis group(56 cases)and combined group(56 cases),respectively.The dialysis group received routine hemodialysis treatment,and the combined group received Bushenxizhuang prescription combined with hemodialysis treatment.All patients were followed up for six months after treatment.The changes in immune function and renal function indicators before and after treatment between the two groups,as well as the occurrence of adverse events after treatment,were compared.Results:After treatment,the total T cells(CD3^(+))and T lymphocyte subsets 4(CD4^(+))in the combined group were higher than those in the dialysis group,and T lymphocyte subsets 8(CD8^(+))were lower than those in the dialysis group,with statistically significant difference(t=3.571,3.169,4.098;P<0.05).After treatment,blood urea nitrogen(BUN),serum creatinine(SCr)and blood uric acid(UA)in combined group were lower than those in dialysis group,and the differences were statistically significant(t=3.291,3.650,3.617;P<0.05).After treatment,the endogenous creatinine clearance rate(CCr)and glomerular filtration rate(GFR)of combined group were higher than those of dialysis group,with statistical significance(t=3.731,3.725;P<0.05).During the follow-up period,the incidence of adverse events in the combined group was 10.71%,which was slightly higher than that in the dialysis group(8.93%),and the difference was not statistically significant(χ^(2)=0.179,P>0.05).Conclusion:The combination of Bushen Xiezhuo Recipe and hemodialysis treatment of CRF can enhance the patient’s immunity and promote the recovery of renal function.This Chinese medicine treatment does not significantly increase the risk of adverse events in patients,wi
作者
聂子牧
姚丽君
Nie Zimu;Yao Lijun(Department of Renal Disease and Rheumatology,Xuchang Municipal Hospital,Xuchang,Henan,461000,China)
出处
《黑龙江医学》
2024年第19期2327-2329,共3页
Heilongjiang Medical Journal
基金
河南省医学科技攻关项目(LHGJ202001126)。
关键词
慢性肾衰竭
补肾泄浊方
血液透析
肾功能
治疗安全性
Chronic renal failure
Kidney tonifying and turbidity relieving formula
Hemodialysis
Renal function
Treatment safety
