摘要
目的 探讨上焦宣痹汤合三仁汤加减结合阿奇霉素治疗儿童肺炎支原体肺炎的临床效果。方法 选取2023年1月至2023年12月高安市妇幼保健院收治的120例肺炎支原体肺炎患儿,按随机数字表法分为两组,各60例。对照组予以阿奇霉素治疗,观察组加用上焦宣痹汤合三仁汤加减治疗,持续2周。比较两组临床疗效、炎症水平、肺功能指标、中医症候积分、症状消失时间及安全性。结果 观察组总有效率高于对照组(P<0.05)。治疗后,观察组IL-6、CRP、TNF-α、PCT水平均低于对照组(P<0.05);观察组FVC、FEV_(1)、PEF、PEF25均高于对照组(P<0.05);观察组身热不扬、咯痰不爽、烦躁、口中黏腻积分均低于对照组(P<0.05);观察组退热、肺啰音消失、咳嗽消失及肺部病灶吸收时间均短于对照组(P<0.05);两组安全性相比,差异无统计学意义(P>0.05)。结论 上焦宣痹汤合三仁汤加减结合阿奇霉素可提高儿童肺炎支原体肺炎治疗效果,降低炎症水平,加快肺功能恢复,促进疾病症状消失,安全可靠。
Objective To explore the clinical effect of modify shangjiao xuanbi decoction and sanren decoction combined with azithromycin in the treatment of children with mycoplasma pneumoniae pneumonia(MPP).Methods 120 children with MPP admitted to Gaoan Maternal and Child Health Hospital from January 2023 to December 2023 were randomly divided into two groups,60 cases in each group.The control group was treated with azithromycin,and the observation group were treated with modify shangjiao xuanbi decoction and sanren decoction combined with azithromycin,all treated for 2 weeks.The clinical efficacy,inflammatory level,lung function index,TCM symptom score,symptom disappearance time and safety of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,IL-6,CRP,TNF-α,PCT levels in the observation group were lower than those of the control group(P<0.05);FVC,FEV_(1),PEF and PEF25 in the observation group were higher than those in the control group(P<0.05);the scores of body heat,expectoration,irritability,and sticky mouth in the observation group were lower than those in the control group(P<0.05);the defervescence,disappearance of pulmonary rales,disappearance of cough and absorption time of pulmonary lesions in the observation group were shorter than those in the control group(P<0.05).There was no difference in safety between the two groups(P>0.05).Conclusion Modify shangjiao xuanbi decoction and sanren decoction combined with azithromycin can improve the therapeutic effect of children with MPP,reduce the level of inflammation,accelerate the recovery of lung function,and promote the disappearance of disease symptoms,which is safe and reliable.
作者
况斌武
梅春香
KUANG Binwu;MEI Chunxiang(Gaoan Maternal and Child Health Hospital,Gaoan Jiangxi 330800,China)
出处
《药品评价》
CAS
2024年第6期760-763,共4页
Drug Evaluation
关键词
儿童肺炎支原体肺炎
上焦宣痹汤合三仁汤
阿奇霉素
炎症水平
安全性
Mycoplasma pneumoniae pneumonia in children
Shangjiao xuanbi decoction and sanren decoction
Azithromycin
Levels of inflammation
Safety
