摘要
外泌体miR-155-5p作为广泛存在于多种细胞类型中的微小RNA,在调控基因表达、细胞增殖、分化、凋亡等方面发挥重要作用。研究表明,外泌体miR-155-5p在多种癌细胞中高表达,并与癌细胞增殖、侵袭、转移等恶性行为密切相关。因此,研究外泌体miR-155-5p在癌细胞增殖、侵袭中的作用具有重要意义和应用价值。本综述旨在通过对外泌体及miR-155-5p进行概述,并详细分析外泌体miR-155-5p在癌细胞增殖、侵袭中的机制,同时探讨其在不同类型癌症中的具体作用,以及评估其作为生物标志物和治疗靶点的潜力,以期为进一步理解外泌体miR-155-5p在癌细胞中的作用机制及临床应用提供理论基础和研究思路。
Exosome miR-155-5p,as a micrornas widely present in many cell types,plays an important role in regulating gene expression,cell proliferation,differentiation,and apoptosis.Studies have shown that Exosome miR-155-5p is highly expressed in a variety of cancer cells and is closely related to malignant behaviors such as cancer cell proliferation,invasion,and metastasis.Therefore,it is of great significance and application value to study the role of exosome miR-155-5p in the proliferation and invasion of cancer cells.This review aims to provide an overview of exosomes and miR-155-5p,analyze the mechanism of exosomes miR-155-5p in cancer cell proliferation and invasion in detail,explore its specific role in different types of cancer,and evaluate its potential as a biomarker and therapeutic target.In order to provide theoretical basis and research ideas for further understanding the mechanism of action and clinical application of exosome miR-155-5p in cancer cells.
作者
田泽芸
TIAN Zeyun(Department of Orthodontics,Tianjin City Children’s Hospital,Tianjin 300000,China)
出处
《中国伤残医学》
2024年第13期156-160,共5页
Chinese Journal of Trauma and Disability Medicine
