摘要
二甲基亚砜是一种具有多种生物学功能的极性有机溶剂,目前在医学领域被作为冷冻保护剂广泛应用于冰冻保存器官及细胞等,其本身具有消炎、镇痛、利尿和镇静等药理作用,且作为医药用品相对安全有效,因此也作为医药溶剂及药物的载体大量用于医药行业和临床给药。近年来,二甲基亚砜的核辐射防护效果研究也受到了广泛关注,此类研究为机体多组织器官放射损伤共性发病机制与防护研究提供了新的思路。然而,其生理学和药理学特性并未被完全阐明,该文就目前国内外关于二甲基亚砜的医学应用及安全性研究予以综述,以期为进一步研究及应用提供参考。
Dimethyl sulfoxide(DMSO)is a polar organic solvent with various biological functions.Currently,it is widely used as a cryoprotectant in the medical field to cryopreserve organs and cells.It has pharmacological effects such as anti-inflammation,analgesia,diuresis and sedation,and is relatively safe and effective as a medical product.Therefore it is widely used in the pharmaceutical industry and clinical administration as a pharmaceutical solvent and drug carrier.In recent years,research on the nuclear radiation protection effect of DMSO has also received much attention,this type of research provides new insights into the common pathogenesis and protection of radiation damage to multiple organs and tissues in the body.However,its physiological and pharmacological properties have not been fully elucidated.This article reviewed the current medical applications and safety of DMSO at home and abroad,with a view to provide references for further research and application.
作者
袁婵
张一波
蒋卓言(综述)
郭若冰(审校)
YUAN Chan;ZHANG Yibo;JIANG Zhuoyan;GUO Ruobing(Ningxia Vocational and Technical College Ningxia Open University,Yinchuan,Ningxia 750001,China;School of Stomatology,Yunnan Medical Health College,Kunming,Yunnan 650032,China;Department of Pharmacy,General Hospital of Ningxia Medical University,Yinchuan,Ningxia 750001,China)
出处
《现代医药卫生》
2024年第19期3381-3386,共6页
Journal of Modern Medicine & Health
关键词
二甲基亚砜
有机溶剂
药理作用
毒性作用
综述
Dimethyl sulfoxide
Organic solvent
Medical application
Toxic effect
Review
