摘要
目的探讨鼻咽癌患者治疗前血脂水平的变化,并探索是否可以作为预测鼻咽癌的指标。方法选取广西壮族自治区人民医院2013-2022年病理确诊并资料齐全的131例鼻咽癌患者作为鼻咽癌组,对照组为随机选取的119名健康体检人员,检测鼻咽癌患者治疗前的血脂参数总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)及脂蛋白a[Lp(a)]值并进行统计学分析。结果鼻咽癌组所有血脂参数与对照组比较,差异均有统计学意义(P<0.0001)。M分期组间比较,其中TC、LDL-C、ApoB差异有统计学意义(P<0.01)。受试者操作特征(ROC)曲线的结果显示,TC、HDL-C、ApoA1、Lp(a)、TC/HDL-C、LDL-C/HDL-C及ApoA1/ApoB的曲线下面积(AUC)>0.7,其中TC/HDL-C、LDL-C/HDL-C及ApoA1/ApoB 3个指标的AUC最大,分别为0.82、0.77、0.75,灵敏度分别为0.70、0.70、0.65,特异度分别为0.88、0.82、0.78,cut-off值分别为>3.97、>2.50、<1.24。结论鼻咽癌患者治疗前的TC、TG、LDL-C、HDL-C、ApoA1、ApoB及Lp(a)水平即发生异常。在M分期中发现鼻咽癌有远处转移组的TC、LDL-C、ApoB相比无远处转移组明显升高。TC/HDL-C、LDL-C/HDL-C和ApoA1/ApoB血脂比值参数可以作为预测鼻咽癌发生的指标,灵敏度和特异度均较好。
Objective To investigate changes in pre-treatment lipid levels in patients with nasopharyngeal carcinoma and to explore whether they can be used as predictors of nasopharyngeal carcinoma.Methods A total of 131 nasopharyngeal cancer patients with pathologically confirmed diagnosis and complete data from 2013-2022 in the People′s Hospital of Guangxi Zhuang Autonomous Region were selected as the nasopharyngeal cancer group,and the control group consisted of 119 randomly selected health checkups,and the lipid parameters of nasopharyngeal cancer patients prior to treatment were detected,including total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),apolipoprotein A1(ApoA1),apolipoprotein B(ApoB)and lipoprotein a[Lp(a)]values were measured and statistically analyzed.Results All lipid parameters in the nasopharyngeal cancer group were statistically significant when compared to the control group(P<0.0001).Comparison between M staging groups,in which the differences in TC,LDL-C,and ApoB were statistically significant(P<0.01).The results of the subjects′operating characteristic(ROC)curves showed that the area under the curve(AUC)of TC,HDL-C,ApoA1,Lp(a),TC/HDL-C,LDL-C/HDL-C and ApoA1/ApoB were>0.7.Among them,the AUC of TC/HDL-C,LDL-C/HDL-C,and ApoA1/ApoB were the highest,at 0.82,0.77,0.75,with sensitivity of 0.70,0.70,0.65,specificity of 0.88,0.82,0.78,and cut-off values of>3.97,>2.50,<1.24,respectively.Conclusion Abnormalities in TC,TG,LDL-C,HDL-C,ApoA1,ApoB,and Lp(a)levels are found in nasopharyngeal cancer patients before treatment.TC,LDL-C and ApoB are found to be significantly higher in the group with distant metastases compare with the group without distant metastases in M staging.TC/HDL-C,LDL-C/HDL-C and ApoA1/ApoB lipid ratio parameters can be used as predictors of nasopharyngeal carcinoma development with good sensitivity and specificity.
作者
黎华
朱松山
殷君
苏航就
LI Hua;ZHU Songshan;YIN Jun;SU Hangjiu(Department of Laboratory Medicine,Jiangbin Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi 530012,China;The First Dongguan Affiliated Hospital,Guangdong Medical University/Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics/Dongguan Key Laboratory of Molecular Immunology and Cell Therapy/School of Medical Technology,Guangdong Medical University,Dongguan,Guangdong 523710,China;Institute of Transplantation Medicine,the Second Affiliated Hospital of Guangxi Medical University/Guangxi Clinical Research Center for Organ Transplantation/Guangxi Key Laboratory of Organ Donation and Transplantation,Nanning,Guangxi 530007,China;Department of Laboratory Medicine,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi 530000,China)
出处
《现代医药卫生》
2024年第19期3276-3280,共5页
Journal of Modern Medicine & Health
基金
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20210444、Z-A20240215、Z-A20230226)。
关键词
鼻咽癌
血脂
诊断
灵敏度
特异度
Nnasopharyngeal carcinoma
Lipids
Diagnosis
Sensitivity
Specificity
