摘要
脑转移是肺癌预后较差的一种疾病类型,既往传统化疗时代,缺乏特异性的治疗手段。但随着靶向治疗药物、免疫治疗药物、抗体偶联药物等诸多药物的发展,肺癌的治疗手段更为丰富。上述治疗方式使肺癌脑转移的治疗效果也有了显著提升。基于此,文章从靶向治疗药物、抗体偶联药物及免疫检查点抑制剂等方面对当前治疗肺癌脑转移的药物进展进行概述,梳理并总结目前可用的手段及未来发展方向,希望对肺癌脑转移的治疗有一定参考意义。
Brain metastasis is a type of lung cancer with a poor prognosis,and during the era of traditional chemotherapy,there was a lack of specific treatment options.However,with the development of targeted therapies,immunotherapies,and antibody-drug conjugates,treatment options for lung cancer have significantly improved.These advancements have also led to notable progress in the treatment of lung cancer brain metastases.Based on this,the article provides an overview of the current therapeutic developments for lung cancer brain metastasis,focusing on targeted therapies,antibody-drug conjugates,and immune checkpoint inhibitors.It reviews and summarizes the available treatments and future directions,aiming to provide valuable insights for improving the treatment of lung cancer brain metastasis.
作者
朱以香
王洁
Zhu Yixiang;Wang Jie(CAMS Key Laboratory of Translational Research on Lung Cancer,State Key Laboratory of Molecular Oncology,Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences Peking Union Medical College,Beijing 100021,China)
出处
《中国肿瘤临床与康复》
2024年第7期397-406,共10页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
国家重点研发计划(2022YFC2505000)
国家自然科学基金(82272796)。
关键词
肺癌
肿瘤转移
脑
靶向治疗
抗体偶联药物
免疫检查点抑制剂
Lung neoplasms
Neoplasms metastasis,brain
Targeted therapy
Antibody-drug conjugate
Immune checkpoint inhibitors
