摘要
目的探讨岭南调神助孕针法联合芬吗通对早发性卵巢功能不全(Premature ovarian insufficiency,POI)患者性激素、自然杀伤细胞(Natural killer cell,NK细胞)和T淋巴细胞的影响。方法选取2022年2月—2023年2月期间就诊于广东医科大学顺德妇女儿童医院门诊的POI患者102例,采用电脑随机数字表法随机分为针刺组和西医组,每组各51例。西医组予以芬吗通口服,针刺组予以岭南调神助孕针法联合芬吗通治疗。3个疗程(3个月经周期)后观察比较两组患者临床疗效及不良反应,评价两组患者治疗前后中医证候积分、改良Kupperman量表评分变化,检测血清性激素指标雌二醇(Estradiol,E2)、卵泡刺激素(Follicle-stimulating hormone,FSH)、黄体生成素(Luteinizing hormone,LH)、抗苗勒管激素(Anti-mullerian hormone,AMH),检测外周血NK细胞与T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))变化。结果治疗后两组患者中医各项证候评分及总积分均较治疗前明显降低,差异有统计学意义(P<0.05);且针刺组中医各项积分及总积分低于西医组,差异有统计学意义(P<0.05)。治疗后两组患者改良Kupperman评分较治疗前降低,差异有统计学意义(P<0.05);且针刺组改良Kupperman评分明显低于西医组,差异有统计学意义(P<0.05)。治疗后两组患者血清E2、AMH水平较治疗前明显升高,FSH、LH水平较治疗前明显降低,差异有统计学意义(P<0.05);且针刺组E2、AMH水平明显高于西医组,FSH、LH水平明显低于西医组,差异有统计学意义(P<0.05)。治疗后两组患者NK细胞、CD8^(+)较治疗前明显降低,CD4^(+)、CD4^(+)/CD8^(+)较治疗前明显升高,差异有统计学意义(P<0.05);且针刺组NK细胞、CD8^(+)明显低于西医组,CD4^(+)、CD4^(+)/CD8^(+)明显高于西医组,差异有统计学意义(P<0.05)。治疗后针刺组临床总有效率98.04%(50/51)明显高于西医组86.27%(44/51),差异有统计学意义(χ2=8.022,P<0.05)。治疗期间,两组�
Objective To explore the effects of Lingnan mind-regulating and pregnancy-assisting acupuncture combined with Femoston on sexual hormones,natural killer cells(NK cells),and T lymphocytes in patients with premature ovarian insufficiency(POI).Methods 102 POI patients who visited the outpatient clinic of the Shunde Women and Children′s Hospital of Guangdong Medical University between February 2022 and February 2023 were selected.They were randomly divided into two groups using a computer-generated random number table:an acupuncture group and a Western medicine group,with 51 patients in each group.The Western medicine group received oral Femoston,while the acupuncture group received Lingnan mind-regulating and pregnancy-assisting acupuncture combined with Femoston.After three treatment courses(three menstrual cycles),the clinical efficacy and adverse reactions of the two groups were observed and compared.Changes in traditional Chinese medicine(TCM)syndrome scores,modified Kupperman scale scores,and serum sex hormones including estradiol(E_(2)),follicle-stimulating hormone(FSH),luteinizing hormone(LH),and anti-Mullerian hormone(AMH)were measured before and after treatment.Additionally,the peripheral blood levels of NK cells and T lymphocyte subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))were analyzed.Results After treatment,the TCM syndrome scores and total scores in both groups were significantly lower compared to before treatment,with statistically significant differences(P<0.05).The acupuncture group had significantly lower TCM syndrome and total scores than the Western medicine group,with statistically significant differences,with statistically significant differences(P<0.05).The modified Kuperman scores also significantly decreased in both groups after treatment,with statistically significant differences(P<0.05);the acupuncture group showed significantly lower scores than the Western medicine group,with statistically significant differences(P<0.05).After treatment,serum E_2 and AMH levels were significantly increased,
作者
吴佳
汪周艳
潘琦琦
陈兴华
WU Jia;WANG Zhou-yan;PAN Qi-qi;CHENX ing-hua(Shunde Women and Children's Hospital of Guangdong Medical University(Matemnity&Child Healthcare Hospital of Shunde Foshan),Foshan Guangdong 528300;Department of Rehabilitation,The First Afiliated Hospital of Guangzhou University of Chinese Mediceine,Guangzhou Guangdong 510405)
出处
《世界中西医结合杂志》
2024年第9期1852-1857,1862,共7页
World Journal of Integrated Traditional and Western Medicine
基金
2024年度广东省中医药局科研项目(20241309)
广东医科大学顺德妇女儿童医院(佛山市顺德区妇幼保健院)博士科研启动经费项目资助(2022BSQD003)。
关键词
早发性卵巢功能不全
岭南调神助孕针法
性激素
NK细胞
T淋巴细胞
免疫
Premature Ovarian Insuficiency
Lingnan Mind-Regulating and Pregnancy-Assisting Acupuncture
.Sexual Hormones
NK Cells
T Lymphocytes
Immune
