摘要
文章旨在研究耐力训练对高脂饲料诱导肥胖小鼠生长性能、血清免疫指标及抗氧化指标的影响。试验将120只3周龄的C57雄性小鼠随机分为3组,每组4个重复,每个重复10只。对照组小鼠饲喂普通饲料,肥胖组小鼠饲喂高脂饲料,耐力训练组小鼠饲喂高脂饲料+跑台运动干预,试验为期4周。结果表明:(1)与对照组相比,肥胖组小鼠末重显著提高36.88%(P<0.05),Lee's指数显著提高10.92%(P<0.05)。与肥胖组相比,耐力训练组小鼠Lee's指数显著降低5.54%(P<0.05)。(2)与对照组和肥胖组相比,耐力训练组小鼠血清免疫球蛋白(IgG)含量显著提高(P<0.05),血清肿瘤坏死因子-α(TNF-α)含量显著降低(P<0.05)。(3)与对照组相比,肥胖组小鼠血清总抗氧化能力、谷胱甘肽过氧化物酶活性显著降低(P<0.05),血清丙二醛含量显著提高(P<0.05)。与肥胖组相比,耐力训练组小鼠血清总抗氧化能力显著提高(P<0.05),血清谷胱甘肽过氧化物酶活性极显著提高(P<0.01),血清丙二醛含量显著降低(P<0.05)。综上所述,高脂饲料容易诱导小鼠的肥胖和氧化应激问题,而通过耐力训练可以降低小鼠Lee's指数,并提高血清免疫力及抗氧化能力。
To investigate the effects of endurance training on the growth performance,serum immune indicators,and antioxidant indicators of high fat feed induced obese mice.Select 1203-week-old C57 male mice and randomly divide them into 3 groups,with 4 replicates in each group and 10 mice per replicate.The control group mice were fed with regular feed,the obese group mice were fed with high fat feed,and the endurance training group mice were fed with high fat feed and treadmill exercise intervention.The experiment lasted for 4 weeks.The results showed that:(1)Compared with the control group,the final weight of obese mice significantly increased by 36.88%(P<0.05),and the Lee's index significantly increased by 10.92%(P<0.05).Compared with the obese group,the Lee's index of mice in the endurance training group was significantly reduced by 5.54%(P<0.05).(2)Compared with the control group and the obesity group,the endurance training group showed a significant increase in serum IgG levels(P<0.05)and a significant decrease in serum TNF-αlevels(P<0.05).(3)Compared with the control group,the serum total antioxidant capacity and glutathione peroxidase activity of obese mice were significantly reduced(P<0.05),and the serum malondialdehyde content was significantly increased(P<0.05).Compared with the obese group,the endurance training group showed a significant increase in serum total antioxidant capacity(P<0.05),a highly significant increase in serum glutathione peroxidase activity(P<0.01),and a significant decrease in serum malondialdehyde content(P<0.05).In summary,high fat feed can easily induce obesity and oxidative stress in mice,while endurance training can reduce the Lee's index of mice and improve serum immunity and antioxidant capacity.
作者
张伟
ZHANG Wei(Songshan Shaolin Wushu College,Zhengzhou,Henan Province 452470,China)
出处
《中国饲料》
北大核心
2024年第18期9-12,共4页
China Feed
关键词
耐力训练
高脂饲料
小鼠
生长性能
血清免疫指标
抗氧化指标
endurance training
high fat feed
mice
growth performance
serum immune indicators
antioxidant indicators
