足月新生儿大脑体积偏侧性分布及与神经行为学的相关性研究

Lateralization of brain volume in term newborns based on MR structural imaging

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摘要目的基于T1加权MR结构成像探究足月新生儿大脑87脑区体积偏侧性的分布特征及脑区体积偏侧性与新生儿行为神经测查法评分之间的相关性。材料与方法回顾性分析2010年11月至2017年9月在西安交通大学第一附属医院行头颅磁共振检查(三维T1WI)的健康足月新生儿64例[胎龄:(39.46±1.17)孕周;男43例,女21例;生后日龄:(10.94±6.90)天],基于Developing Human Connectome Project(dHCP)87脑区分割模板,在联影智能科研平台(uAI Research Portal)利用深度学习分割技术获得新生儿大脑87脑区体积,进而计算偏侧性系数(lateralization index,LI)=100×(V_(L)-V_(R))/(V_(L)+V_(R)),(V:脑区体积),运用t检验及Pearson偏相关探究大脑区域体积偏侧性特征及LI与行为神经测查法评分之间的相关性。结果新生儿期大脑区域体积左侧偏向性(LI>0)主要分布在枕叶、丘脑、尾状核、侧脑室及小脑等区域;右侧偏向性(LI<0)主要分布在海马、扣带回、颞叶及岛叶白质等区域。其中,枕叶白质(r=-0.303,P=0.015)、枕叶灰质(r=-0.315,P=0.012)、海马(r=-0.332,P<0.01)及扣带回后部白质(r=-0.263,P=0.035)的LI与主动肌张力评分之间存在相关性;此外并未发现各脑区的LI与行为能力评分之间存在相关性。结论新生儿期大脑区域体积已呈现出显著的偏侧性特征,脑区体积偏侧性分布范围广泛,且以右侧偏向性为主;主动肌张力在枕叶灰、白质、海马及扣带回后部白质呈右半球优势分布。 Objective:To explore the volumetric lateralization characteristics in 87 distinct brain regions of term newborns and the correlation between lateralization and neurobehavior,utilizing T1-weighted MR structural imaging.Materials and Methods:A retrospective analysis was conducted on 64 healthy full-term newborns who underwent cranial MRI(3D T1WI)at the First Affiliated Hospital of Xi'an Jiaotong University from November 2010 to September 2017.The subjects had an average gestational age of(39.46±1.17)weeks,male/female distribution of 43/21,and average postnatal age of(10.94±6.90)days.Employing deep learning segmentation techniques based on the Developing Human Connectome Project(dHCP)template within the uAI Research Portal,we acquired volumetric data for 87 neonatal brain regions.Subsequently,the lateralization index(LI)was computed as:LI=100×(V_(L)-V_(R))/(V_(L)+V_(R)),(V:volume).Statistical analysis involved t-tests and Pearson's partial correlation to explore the volumetric laterality patterns across brain regions and the correlation between LI and neurobehavior.Results:Analysis revealed left-sided bias(LI>0)in brain region volumes during the neonatal phase,primarily located in the occipital lobe,thalamus,caudate nucleus,lateral ventricles and cerebellum.Conversely,right-sided bias(LI<0)mainly distributed in the hippocampus,cingulate gyrus,temporal lobe and insula white matter.Among them,there was a correlation between LI and active muscle tone scores in occipital white matter(r=-0.303,P=0.015),occipital gray matter(r=-0.315,P=0.012),hippocampus(r=-0.332,P<0.01)and posterior cingulate white matter(r=-0.263,P=0.035).However,no significant correlation was found between LI and behavioral ability scores in any brain region.Conclusions:The neonatal period manifests substantial lateralization characteristics in brain region volumes,characterized by a widespread distribution of lateralized brain volumes and a predominantly right-sided bias.Meanwhile,active muscle tone predominantly localizes to the right hemisphere i

作者白鹏轩冯钰莹朱琳琳刘聪聪夏雨薇石峰李贤军金超杨健赵慧芳 BAI Pengxuan;FENG Yuying;ZHU Linlin;LIU Congcong;XIA Yuwei;SHI Feng;LI Xianjun;JIN Chao;YANG Jian;ZHAO Huifang(Department of Radiology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Shaanxi Engineering Research Center of Computational lmaging and Medical lntelligence,Xi'an 710061,China;Department of Research and Development,Shanghai United Imaging Intelligence Co.,Ltd.,Shanghai 200232,China)

机构地区西安交通大学第一附属医院医学影像科陕西省计算影像与医疗智能工程技术研究中心上海联影智能医疗科技有限公司人工智能研究院

出处《磁共振成像》 CAS CSCD 北大核心 2024年第9期18-22,28,共6页 Chinese Journal of Magnetic Resonance Imaging

基金国家自然科学基金面上项目(编号:82271517、81771810、81971581) 陕西省创新能力支撑计划项目(编号:2019TD-018) 陕西省自然科学基础研究计划项目(编号:2022JM-464) 西安交通大学第一附属医院临床研究课题重点项目(编号:XJTU1AF-CRF-2020-005)。

关键词足月新生儿结构偏侧性主动肌张力磁共振成像 full-term neonates structural asymmetry active muscle tone magnetic resonance imaging

分类号 R445.2 [医药卫生—影像医学与核医学] R722.1 [医药卫生—诊断学]