摘要
免疫应答发生在各种细胞应激中,严重扰乱内质网(ER)功能,导致错误折叠或未折叠蛋白在ER管腔积聚,从而引起内质网应激(ERS)。ERS触发未折叠蛋白反应以恢复ER稳态,但持续时间过长,可导致细胞凋亡。虽然持续的ERS可导致促炎细胞因子增加从而诱导炎症反应,激活免疫应答,但ERS与免疫应答间的因果关系尚无定论。本文综述了ERS在诱导免疫细胞分化、细胞因子表达、免疫功能中的作用,进一步阐述免疫细胞ERS在免疫紊乱发病机制中的调控作用,有助于挖掘针对ERS相关疾病的新疗法。
Immune response occurs in a variety of cellular stresses that severely disrupt function of endoplasmic reticulum(ER),leading to accumulation of misfolded or unfolded protein in ER lumen,resulting in endoplasmic reticulum stress(ERS).ERS triggers unfolded protein response to restore ER homeostasis,but its duration is too long and can lead to cell apoptosis.Although sustained ERS can lead to an increase in pro-inflammatory cytokines that induce inflammatory responses and activate immune responses,causal relationship between ERS and immune responses has not been established.This review summarizes role of ERS in inducing immune cell differentiation,cytokine expression and immune function,and further illustrates regulatory role of ERS in pathogenesis of immune disorders,which is helpful to explore new therapies for ERS-related diseases.
作者
卢桃
张茵
李川
林世德
LU Tao;ZHANG Yin;LI Chuan;LIN Shide(Department of Infectious Diseases,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2024年第9期2011-2016,F0003,F0004,共8页
Chinese Journal of Immunology
基金
国家自然科学基金(81860114)。
关键词
内质网应激
免疫细胞
免疫紊乱
新疗法
Endoplasmic reticulum stress
Immune cells
Immune disorders
New therapies
