摘要
目的:探究经鼻型肠梗阻导管联合奥曲肽注射液对炎性肠梗阻患者胃肠功能的影响。方法:选择2021年6月—2023年6月福州市长乐区人民医院收治的90例炎性肠梗阻患者作为研究对象,根据随机数表法将患者分为对照组45例和观察组45例。对照组采用奥曲肽注射液进行治疗,观察组则采用经鼻型肠梗阻导管联合奥曲肽注射液进行治疗。比较两组治疗总有效率、胃肠相关症状体征改善时间(腹痛腹胀改善时间、肠鸣音恢复时间、排气时间及排便时间)、治疗前后胃肠激素[血管活性肠肽(VIP)、胃动素(MTL)及胃泌素(GAS)]及肠黏膜屏障[二胺氧化酶(DAO)、内毒素(ET)及D-乳酸(D-Lac)]。结果:观察组治疗总有效率显著高于对照组,胃肠相关症状体征改善时间显著短于对照组,差异有统计学意义(P<0.05)。治疗前,两组胃肠激素、肠黏膜屏障比较,差异无统计学意义(P>0.05);治疗3 d、5 d后,两组VIP、DAO、ET及D-Lac低于治疗前,且观察组低于对照组,两组MTL、GAS高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:经鼻型肠梗阻导管联合奥曲肽注射液在炎性肠梗阻患者中的疗效较好,可显著改善胃肠功能状态。
Objective:To investigate the influence of transnasal intestinal obstruction catheter combined with Octreotide Injection for gastrointestinal function of patients with inflammatory intestinal obstruction.Method:A total of 90 patients with inflammatory intestinal obstruction in who treated in Fuzhou Changle People's Hospital from June 2021 to June 2023 were selected as the study objects,they were divided into the control group of 45 cases and the observation group of 45 cases according to the random number table method.The control group was treated with Octreotide Injection,the observation group was treated with transnasal intestinal obstruction catheter combined with Octreotide Injection.The total effective rate of treatment,improvement time of gastrointestinal related symptoms and signs(improvement time of abdominal pain and distension,recovery time of bowel sounds,exhaust and defecation time),gastrointestinal hormones[vasoactive intestinal peptide(VIP),motilin(MTL)and gastrin(GAS)]and intestinal mucosal barrier[diamine oxidase(DAO),endotoxin(ET)and D-lactic acid(D-Lac)]before and after treatment were compared between two groups.Result:The total effective rate of treatment in the observation group was significantly higher than that in the control group,and the improvement time of gastrointestinal related symptoms and signs were significantly shorter than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the gastrointestinal hormones and intestinal mucosal barrier between two groups(P>0.05);after 3 d and 5 d of treatment,the VIP,DAO,ET and D-Lac in two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the MTL and GAS in two groups were higher than those before treatment,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of transnasal intestinal obstr
作者
陈仁发
CHEN Renfa(Fuzhou Changle People's Hospital,Fuzhou 350200,China)
出处
《中外医学研究》
2024年第26期54-57,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
经鼻型肠梗阻导管
奥曲肽注射液
炎性肠梗阻
胃肠功能
Transnasal intestinal obstruction catheter
Octreotide injection
Inflammatory intestinal obstruction
Gastrointestinal function
