摘要
目的:探讨结直肠癌患者肠道菌群失调与血清降钙素原(PCT)及免疫球蛋白水平的相关性。方法:将2023年1月至2024年2月于我院就诊的61例结直肠癌患者,根据是否存在肠道菌群失调分组,38例无肠道菌群失调者作为对照组,23例存在肠道菌群失调者作为观察组。比较观察组与对照组以及不同程度肠道菌群失调患者血清PCT及免疫球蛋白A(IgA)、IgG、IgM水平的差异,并分析各指标与肠道菌群失调的相关性。结果:观察组患者血清PCT水平明显高于对照组,IgA、IgG、IgM水平明显低于对照组,P<0.05。Ⅰ、Ⅱ、Ⅲ度肠道菌群失调者血清PCT水平依次递增,且两两组间差异均有统计学意义,P<0.05;Ⅰ、Ⅱ、Ⅲ度肠道菌群失调者血清IgA、IgG、IgM水平依次降低,且两两组间差异均有统计学意义,P<0.05。观察组患者肠道肠球菌数量多于对照组,双歧杆菌、乳杆菌、真杆菌数量少于对照组,P<0.05。结直肠癌患者肠道菌群失调程度与血清PCT水平呈正相关,与血清IgA、IgG、IgM水平呈负相关,P<0.05。结论:存在肠道菌群失调的结直肠癌患者中,血清PCT含量明显升高,IgA、IgG、IgM水平明显下调,且其表达水平与肠道菌群失调程度有明显相关性。
Objective To investigate the correlation between intestinal flora imbalance and serum levels of procalcitonin(PCT)and immunoglobulin in patients with colorectal cancer.Methods Total 61 patients with colorectal cancer admitted to our hospital from January 2023 to February 2024 were divided according to whether they had intestinal flora imbalance.Among them,38 patients without intestinal flora imbalance were selected as the control group,while 23 patients with intestinal flora imbalance were selected as the observation group.The serum levels of PCT,IgA,IgG and IgM were compared between the observation group and the control group,as well as the patients with different degrees of intestinal flora imbalance,and the correlation between each index and intestinal flora imbalance was analyzed.Results The serum level of PCT in the observation group was significantly higher than that in the control group,and the levels of IgA,IgG and IgM were significantly lower than those in the control group(P<0.05).The serum level of PCT in patients with degree Ⅰ,Ⅱ and Ⅲ of intestinal flora imbalance was increased successively,and the difference between the two groups was statistically significant(P<0.05).The serum levels of IgA,IgG and IgM in patients with degree Ⅰ,Ⅱand Ⅲ of intestinal flora imbalance were decreased successively,and the differences between the two groups were statistically significant(P<0.05).The number of enterococcus in the observation group was higher than that in the control group,and the number of Bifidobacterium,Lactobacillus and Eubacteria in the observation group was lower than that in the control group(P<0.05).The degree of intestinal flora imbalance in colorectal cancer patients was positively correlated with the serum level of PCT,and negatively correlated with the serum levels of IgA,IgG and IgM(P<0.05).Conclusion In colorectal cancer patients with intestinal flora imbalance,serum level of PCT is significantly increased,IgA,IgG,IgM levels are significantly decreased,and their expression levels ar
作者
仝静
陈向阳
胡亚会
程燕洁
TONG Jing;CHEN Xiang-yang;HU Ya-hui;CHENG Yan-jie(Department of Clinical Laboratory,Fifth Clinical Medical College of Henan University of TCM(Zheng-zhou People's Hospital),Zhengzhou,Henan 450000)
出处
《中国肛肠病杂志》
2024年第8期26-28,共3页
Chinese Journal of Coloproctology
关键词
血清降钙素原
免疫球蛋白
结直肠癌
肠道菌群失调
相关性
Serum procalcitonin
Immunoglobulin
Colorectal cancer
Intestinal flora imbalance
Correlation
