摘要
目的:观察生津汤对气阴两虚型原发性干燥综合征(primary Sjögren′s Syndrome,pSS)患者血清水通道蛋白5(aquaporin 5,AQP5)、白细胞介素10(interleukin-10,IL-10)、IL-17等表达的影响。方法:将60例气阴两虚型pSS女性患者随机分为中药组和西药组各30例,中药组予生津汤,西药组予硫酸羟氯喹片,连续治疗12周后比较两组患者治疗前后中医症状评分、SchirmerⅠ试验值及血清免疫球蛋白G(immunoglobulin G,IgG)、C反应蛋白(C-reaction protein,CRP)、AQP5、IL-17、IL-10表达水平。结果:治疗后两组患者中医症状积分及血清IgG、CRP、IL-17表达降低,SchirmerⅠ试验值、IL-10、AQP5表达升高(P<0.05),除CRP外,中药组其余各指标改善程度均优于西药组(P<0.05)。结论:基于酸甘化阴理论的生津汤能改善pSS患者临床症状,其作用机制可能与生津汤能调节AQP5及IL-17、IL-10等炎症因子表达,抑制机体炎症反应有关。
Objective:To observe the influence of Shengjin Tang(body fluid-generating decoction)on the expressions of AQP5,IL-10 and IL-17 in patients suffering Qi and Yin deficiency pattern primary Sjögren's syndrome(pSS).Methods:Sixty patients were randomly allocated to TCM group and Western medicine group with 30 cases in each group,TCM group took body fluid-generating decoction,and hydroxychloroquine sulfate tablets were dispensed to Western medicine group,both groups were treated for 12 weeks consecutively,to compare TCM symptom scales,SchirmerⅠtest values,the expressions of IgG,CRP,AQP5,IL-17 and IL-10 in the two groups before and after the treatment.Results:After the treatment,TCM symptom scores,and the expressions of IgG,CRP and IL-17 lowered in the two groups,SchirmerⅠtest values,the expressions of IL-10 and AQP5 increased(P<0.05),except for CRP,the improvements of other indexes of TCM group were better than these of Western medicine group(P<0.05).Conclusion:Body fluid-generating decoction,on the foundation of the theory of sour-sweet transformed into Yin,could improve pSS patients'clinical symptoms,and its mechanism might be related to that the decoction could regulate the expressions of AQP5,IL-17 and IL-10,and inhibit inflammatory response in human body.
作者
张艺凡
孙明辉
ZHANG Yifan;SUN Minghui(Clinical Laboratory Center,The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)
出处
《西部中医药》
2024年第9期136-139,共4页
Western Journal of Traditional Chinese Medicine
基金
辽宁省自然科学基金(2014020049)。
关键词
原发性干燥综合征
水通道蛋白5
炎症因子
中医症状积分
酸甘化阴理论
生津汤
primary Sjögren's syndrome
AQP5
inflammatory factors
TCM symptom scores
the theory of sour-sweet transformed into Yin
body fluid-generating decoction
