摘要
缺乏催化活性的蛋白激酶被称为假激酶,其不依赖催化功能在细胞信号转导中起关键作用。富含伪足的非典型激酶2(pseudopodium-enriched atypical kinase 2,PEAK2)是一种Ⅰ类假激酶,在各个器官中广泛表达,包括食管、胰腺、结肠、小肠、肺、胃、肾脏、脾脏和脑等。PEAK2作为支架蛋白是多种信号转导途径的重要组成部分,也是细胞增殖、迁移、侵袭、黏附等过程的关键调节因子。由于PEAK2的表达与肿瘤密切相关,引起科研人员的广泛关注。本文主要从PEAK2的结构、与其相关的信号转导、在疾病中的表达及作用等研究进展进行综述,以期为这些疾病的创新药物发现提供新的思路。
Protein kinases lacking catalytic activity are called pseudokinases,whose catalysis-independent functions play a key role in cell signaling.Pseudopo-dium-enriched atypical kinase 2(PEAK2)is a classⅠpseudokinase that is widely expressed in various organs,including esophagus,pancreas,colon,small intestine,lung,stomach,kidney,spleen,brain and so on.Its role as a scaffold protein is not only an important component of several signal transduction pathways,but also a key regulator of cell proliferation,migration,invasion,adhesion,and other processes.Because the expression of PEAK2 is closely related to tumors and other diseases,it has attracted wide attention.This paper mainly summarizes the research progress of PEAK2 from structure,the related signal transduction and the expression and function in diseases,in order to provide new ideas for innovative drug discovery in these diseases.
作者
高福花
彭益俊
尹姣姣
田碧霞
张翀
GAO Fuhua;PENG Yijun;YIN Jiaojiao;TIAN Bixia;ZHANG Chong(Clincal Laboratory Center of Gansu Provincial Maternal and Child Health Care Hospital,Gansu Provincial Central Hospital,Lanzhou 730050,China)
出处
《生命的化学》
CAS
2024年第8期1384-1391,共8页
Chemistry of Life
基金
甘肃省科技计划项目(22JR5RA716)。
关键词
假激酶
富含伪足的非典型激酶2
信号转导
富含伪足的非典型激酶1
pseudokinase
pseudopodium-enriched atypical kinase 2
signal transduction
pseudopodiumenriched atypical kinase 1
