摘要
目的探讨血清中性粒细胞与淋巴细胞比值(NLR)及鸢尾素在类风湿关节炎(RA)患者中的表达情况,以及与疾病活动度及骨密度的相关性。方法选取2022年4月至2024年4月陕西省核工业二一五医院收治的123例RA患者作为观察组进行回顾性研究,根据疾病活动度分为低等活动度组(27例)、中度活动度组(58例)以及高等活动度组(38例)。选取50例同期体检的健康成年人作为对照组。观察组中男39例,女84例,年龄(47.49±9.31)岁,体重指数(21.41±1.72)kg/m^(2);对照组中男14例,女36例,年龄(48.02±10.08)岁,体重指数(21.39±1.66)kg/m^(2)。通过血清样本分析NLR和鸢尾素的表达水平,并分析其与疾病活动度及骨密度的相关性。采用独立样本t检验、方差分析、χ^(2)检验、Spearman相关性分析、Pearson相关性分析。结果观察组患者NLR(3.35±0.83)、鸢尾素(195.74±24.39)μg/L,对照组分别为(1.85±0.72)、(258.93±41.84)μg/L,差异均有统计学意义(t=11.179、12.381,均P<0.001)。低等活动度组患者NLR(2.46±0.22)、鸢尾素(213.84±12.27)μg/L,中度活动度组分别为(3.15±0.31)、(195.93±16.98)μg/L,高等活动度组分别为(4.39±0.55)、(184.27±9.14)μg/L,差异均有统计学意义(F=216.474、35.360,均P<0.001)。观察组患者的股骨颈骨密度(0.75±0.12)g/cm^(2)、总髋关节骨密度(0.82±0.11)g/cm^(2)、腰椎骨密度(0.84±0.09)g/cm^(2)、大转子骨密度(0.90±0.18)g/cm^(2),对照组分别为(0.89±0.09)g/cm^(2)、(0.96±0.08)g/cm^(2)、(0.97±0.10)g/cm^(2)、(1.05±0.23)g/cm^(2),差异均有统计学意义(均P<0.05)。采用Spearman相关性分析,血清NLR与疾病活动度存在正相关(r=0.879,P<0.001),血清鸢尾素水平与疾病活动度存在负相关(r=-0.615,P<0.001)。采用Pearson相关性分析,血清NLR与股骨颈、总髋关节、腰椎、大转子骨密度均存在负相关(r=-0.358、-0.366、-0.525、-0.174,均P<0.05),血清鸢尾素水平与股骨颈、总髋关节、腰椎、大转子骨密度�
Objective To explore the expression levels of serum neutrophil-to-lymphocyte ratio(NLR)and irisin in patients with rheumatoid arthritis(RA)and their correlations with disease activity and bone density.Methods A total of 123 RA patients admitted to No.215 Hospital of Shaanxi Nuclear Industry from April 2022 to April 2024 were selected as the observation group for a retrospective study.According to the disease activity,they were divided into a low activity group(27 cases),a moderate activity group(58 cases),and a high activity group(38 cases).Additionally,50 healthy adults who underwent physical examination during the same period were selected as the control group.In the observation group,there were 39 males and 84 females,aged(47.49±9.31)years,with a body mass index(BMI)of(21.41±1.72)kg/m^(2).In the control group,there were 14 males and 36 females,aged(48.02±10.08)years,with a body mass index of(21.39±1.66)kg/m^(2).Serum samples were analyzed for NLR and irisin levels,and their correlations with disease activity and bone density were assessed.Independent sample t test,ANOVA,χ^(2)test,Spearman correlation analysis,and Pearson correlation analysis were used.Results The levels of NLR(3.35±0.83)and irisin(195.74±24.39)μg/L in the observation group were higher than those in the control group[(1.85±0.72)and(258.93±41.84)μg/L],with statistically significant differences(t=11.179 and 12.381,both P<0.001).The levels of NLR and irisin were(2.46±0.22)and(213.84±12.27)μg/L in the low activity group,(3.15±0.31)and(195.93±16.98)μg/L in the moderate activity group,(4.39±0.55)and(184.27±9.14)μg/L in the high activity group,with statistically significant differences(F=216.474 and 35.360,both P<0.001).The bone mineral density of femoral neck[(0.75±0.12)g/cm^(2)],total hip joint[(0.82±0.11)g/cm^(2)],lumbar spine[(0.84±0.09)g/cm^(2)],and greater trochanter[(0.90±0.18)g/cm^(2)]in the observation group were lower than those in the control group[(0.89±0.09)g/cm^(2),(0.96±0.08)g/cm^(2),(0.97±0.10)g/cm^(2),and(1.
作者
王凤
韩钢
Wang Feng;Han Gang(Department of Rheumatology and Immunology,No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China;Department of Traditional Chinese Medicine Orthopaedics,The Second Affiliated Hospital of Xi'an Medical University,Xi'an 710000,China)
出处
《国际医药卫生导报》
2024年第20期3418-3422,共5页
International Medicine and Health Guidance News
基金
陕西省重点研发计划(2022SF-280)。
