摘要
目的:探究麻杏泻白散联合西药对结缔组织病相关性间质性肺疾病急性加重期患者临床疗效、肺功能、肿瘤标志物以及安全性的影响,为提升该疾病的临床治疗效果提供依据。方法:随机数字表法将安阳市中医院2022年2月—2023年2月收治的100例结缔组织病相关性间质性肺疾病急性加重期患者分为2组,采用西药(醋酸泼尼松片+复方环磷酰胺片)治疗为对照组,采用麻杏泻白散联合西药治疗为观察组,每组均为50例,2组均连续治疗6个月。比较2组患者临床疗效,治疗前后2组肺功能(第1秒用力呼气容积、用力肺活量、CO弥散量)、肿瘤标志物(癌胚抗原、神经原特异性烯醇化酶、糖类抗原199、糖类抗原125)、血清学指标(白细胞介素6、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值),以及治疗期间发生不良反应的情况。结果:观察组有效率高于对照组;与治疗前比,经6个月治疗后2组患者第1秒用力呼气容积、用力肺活量、CO弥散量水平均上升,观察组比对照组高;与治疗前比,经6个月治疗后2组患者癌胚抗原、神经原特异性烯醇化酶、糖类抗原199、糖类抗原125水平均下降,观察组比对照组低;与治疗前比,经6个月治疗后2组患者白细胞介素-6、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值均下降,观察组比对照组低,差异均有统计学意义;治疗期间观察组不良反应发生率低于对照组,差异无统计学意义。结论:麻杏泻白散联合西药治疗结缔组织病相关性间质性肺疾病急性加重期患者疗效显著,能够改善患者肺功能,减轻机体炎症反应,降低机体肿瘤标志物表达水平,且安全性良好。
Objective:To explore the effects of Maxing Xiebai powder combined with western medicine on clinical efficacy,lung function,tumor markers and safety in patients with acute exacerbation of connective tissue disease-related interstitial lung disease,so as to provide a basis for improving the clinical treatment effect of the disease.Methods:A total of 100 patients with acute exacerbation of connective tissue disease-related interstitial lung disease admitted to Anyang Hospital of Traditional Chinese Medicine from February 2022 to February 2023 were divided into 2 groups by random number table method.The control group was treated with western medicine(prednisone acetate tablets+compound cyclophosphamide tablets),and the observation group was treated with Maxing Xiebai powder combined with western medicine.There were 50 cases in each group,and both groups were treated for 6 consecutive months.The two groups were compared in terms of clinical efficacy,lung function(forced expiratory volume in 1 second,forced vital capacity,CO diffusion capacity),tumor markers(carcinoembryonic antigen,neuron-specific enolase,carbohydrate antigen 199,carbohydrate antigen 125),serological indicators(interleukin-6,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio)before and after treatment,and adverse reactions during treatment.Results:The effective rate of the observation group was higher than that of the control group.Compared with before treatment,after 6 months of treatment,the forced expiratory volume in 1 second,forced vital capacity and CO diffusion capacity of the two groups of patients increased,and the observation group was higher than that of the control group.Compared with before treatment,after 6 months of treatment,the levels of carcinoembryonic antigen,neuron-specific enolase,carbohydrate antigen 199 and carbohydrate antigen 125 of the two groups of patients decreased,and the observation group was lower than that of the control group.Compared with before treatment,after 6 months of treatment,the levels of interleuki
作者
李华
李珂
LI Hua;LI Ke(Anyang Hospital of Traditional Chinese Medicine,Henan Anyang 455100,China)
出处
《中医药临床杂志》
2024年第9期1768-1772,共5页
Clinical Journal of Traditional Chinese Medicine
关键词
结缔组织病
相关性间质性肺疾病
麻杏泻白散
Connective tissue disease
Related interstitial lung disease
Maxing Xiebai powder
