摘要
目的:观察参芪清毒汤治疗维持性血液透析(MHD)患者的临床疗效及对其营养状况及、高凝状态的影响。方法:采用随机数字表法将117例MHD患者分为对照组(59例)和观察组(58例)。对照组给予常规MHD和基础治疗,观察组在对照组基础上加用参芪清毒汤治疗。2组治疗时间均为6个月。比较2组临床疗效及不良反应,治疗前后中医证候评分、营养状况及血液高凝指标[全血低切黏度、血高切黏度、血浆黏度及血浆纤维蛋白原(Fib)、D-二聚体(D-D)、凝血活酶时间(APTT)]水平。结果:治疗后,观察组总有效率98.28%,对照组为83.05%,组间比较,差异有统计学意义(P<0.05)。治疗后,2组脘腹胀满、倦怠乏力、腰膝酸软等证候评分及总分均较治疗前降低(P<0.05),且观察组上述各项评分均低于对照组(P<0.05)。治疗后,2组营养良好患者占比均较治疗前升高(P<0.05),且观察组占比高于对照组(P<0.05);2组重度营养不良患者占比均较治疗前降低(P<0.05),且观察组占比低于对照组(P<0.05)。治疗后,2组全血高切黏度、全血低切黏度、血浆黏度及血浆APTT、Fib、D-D水平均较治疗前降低(P<0.05),且观察组上述各项指标均低于对照组(P<0.05)。治疗期间,观察组不良反应发生率为6.90%,对照组为10.17%,2组比较,差异无统计学意义(P>0.05)。结论:参芪清毒汤治疗MHD患者可提高临床疗效,有效改善患者中医证候、血液高凝状态及营养状况。
Objective:To observe the clinical effect of Shenqi Qingdu Decoction on maintenance hemodialysis(MHD)patients and its effect on nutritional status and hypercoagulable state.Methods:A total of 117 MHD patients were divided into the control group(59 cases)and the observation group(58 cases)using a random number table method.The control group was given routine MHD and basic treatment,and the observation group was treated with Shenqi Qingdu Decoction in addition to the treatment in the control group.Both groups were treated for six months.The clinical effects and adverse reactions were compared between the two groups.The levels of traditional Chinese medicine(TCM)syndrome scores,nutritional status,and blood hypercoagulability indicators[whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,and plasma fibrinogen(Fib),D-dimer(D-D),and activated partial thromboplastin time(APTT)]were compared before and after treatment.Results:After treatment,the total effective rate was 98.28%in the observation group,and 83.05%in the control group,and there was significant difference between the two groups(P<0.05).After treatment,the TCM syndrome scores of abdominal distension and fullness,fatigue and lack of strength,and waist and knee soreness,as well as the total scores in both groups were decreased when compared with those before treatment(P<0.05),and the observation group had lower scores than the control group in all the above aspects(P<0.05).After treatment,the proportion of patients with good nutrition in the two groups were increased when compared with those before treatment(P<0.05),and the proportion of patients in the observation group was higher than that in the control group(P<0.05);the proportion of severe malnutrition patients in both groups were declined when compared with those before treatment(P<0.05),and the proportion in the observation group was lower than that in the control group(P<0.05).After treatment,the whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosit
作者
王燕
程茜茜
马舒雅
WANG Yan;CHENG Qianqian;MA Shuya(Department of Nephrology,Medical Community Headquarters,Shaoxing City Keqiao District Hospital of Traditional Chinese Medicine,Shaoxing Zhejiang 312050,China;Endocrinology Department,Medical Community Headquarters,Shaoxing City Keqiao District Hospital of Traditional Chinese Medicine,Shaoxing Zhejiang 312050,China)
出处
《新中医》
CAS
2024年第18期83-87,共5页
New Chinese Medicine
关键词
维持性血液透析
参芪清毒汤
营养状况
高凝状态
Maintenance hemodialysis
Shenqi Qingdu Decoction
Nutritional status
Hypercoagu‐lable state
