摘要
目的探讨红细胞平均血红蛋白浓度(MCHC)、红细胞平均容积(MCV)、平均红细胞血红蛋白含量(MCH)及红细胞体积分布宽度(RDW)在缺铁性贫血与地中海贫血贫血鉴别诊断中的应用价值。方法选择2021年1月至2022年12月于本院接受检查的88例缺铁性贫血患者作为缺铁性贫血组,88例地中海贫血患者作为地中海贫血组,另将同期本院的88名健康体检者纳入对照组。三组研究对象均行血常规检验,比较MCHC、MCV、MCH及RDW对缺铁性贫血及地中海贫血的诊断结果,并分析各指标单项或联合检验对这两种疾病的诊断效能。结果地中海贫血组的MCHC、MCV高于缺铁性贫血组,RDW低于缺铁性贫血组(P<0.001);缺铁性贫血组的MCHC、MCV及MCH低于对照组,RDW高于对照组(P<0.001);地中海贫血组的MCV、MCH明显低于对照组(P<0.001)。MCHC+MCV+MCH+RDW检验对缺铁性贫血诊断的灵敏度、阴性预测值高于MCHC、MCV及MCH检验,诊断符合率高于MCH检验(P<0.05)。MCHC+MCV+MCH+RDW检验对地中海贫血诊断的灵敏度、阴性预测值及诊断符合率高于MCV、MCH检验(P<0.05)。结论贫血患者的MCHC、MCV、MCH及RDW与健康人群有显著差异;四项指标联合检验能够为缺铁性贫血与地中海贫血的鉴别诊断提供参考依据,且可提高对这两种贫血疾病的诊断效能。
Objective To explore the application value of mean corpuscular hemoglobin concentration(MCHC),mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH)and red blood cell volume distribution width(RDW)in the differential diagnosis of iron deficiency anemia and thalassemia.Methods A total of 88 patients with iron deficiency anemia who were examined in our hospital from January 2021 to December 2022 were selected as iron deficiency anemia group,and 88 patients with thalassemia were selected as thalassemia group.In addition,88 healthy subjects in our hospital during the same period were included in control group.All three groups of research objects underwent blood routine tests,and the diagnostic results of MCHC,MCV,MCH and RDW for iron deficiency anemia and thalassemia were compared,and the diagnostic efficacy of single or combined test of each indexes for these two diseases was analyzed.Results MCHC and MCV in the thalassemia group were higher than those in the iron deficiency anemia group,and RDW was lower than that in the iron deficiency anemia group(P<0.001);MCHC,MCV and MCH in the iron deficiency anemia group were lower than those in the control group,and RDW was higher than that in the control group(P<0.001);MCV and MCH in the thalassemia group were significantly lower than those in the control group(P<0.001).The sensitivity and negative predictive value of MCHC+MCV+MCH+RDW test for the diagnosis of iron deficiency anemia were higher than those of MCHC,MCV and MCH tests,and the diagnostic coincidence rate was higher than that of MCH test(P<0.05).The sensitivity,negative predictive value and diagnostic coincidence rate of MCHC+MCV+MCH+RDW tests in the diagnosis of thalassemia were higher than those of MCV and MCH tests(P<0.05).Conclusion MCHC,MCV,MCH and RDW in anemia patients are significantly different from those in healthy people.The combined test of the four indexes can provide a reference for the differential diagnosis of iron deficiency anemia and thalassemia,and can improve the diagnostic efficacy of
作者
杨龙
YANG Long(the People's Hospital of Shanyang County,Shangluo 726400,China)
出处
《临床医学研究与实践》
2024年第27期114-117,共4页
Clinical Research and Practice
关键词
血常规检验
缺铁性贫血
地中海贫血
blood routine test
iron deficiency anemia
thalassemia
