摘要
目的探究结直肠癌患者经奥沙利铂治疗所致神经毒性发生的影响因素。方法前瞻性研究。抽取2021年3月至2023年2月于河南省人民医院确诊并接受奥沙利铂治疗的107例结直肠癌患者为研究对象,统计患者神经毒性的发生情况,将奥沙利铂相关神毒性发生者纳入发生组,其他纳入未发生组。统计并记录研究所需资料,重点分析结直肠癌患者经奥沙利铂治疗后相关神经毒性发生的影响因素。结果107例结直肠癌患者,经奥沙利铂治疗后发生神经毒性反应86例,发生率为80.37%(86/107)。发生组TNM分期为Ⅲ期、合并糖尿病、外周静脉输注占比高于未发生组,且奥沙利铂累积剂量、输注速度均高于未发生组(P<0.05)。Logistic回归模型分析结果显示,TNM分期、合并糖尿病、输注方式、奥沙利铂累积剂量、输注速度均可能是结直肠癌患者经奥沙利铂治疗后相关神经毒性发生的危险因素(OR均>1,P均<0.05)。结论TNM分期、合并糖尿病、药物输注方式、累积剂量、输注速度均可能是结直肠癌患者经奥沙利铂治疗后相关神经毒性发生的危险因素。
Objective To investigate the influencing factors of neurotoxicity caused by oxaliplatin therapy in colorectal cancer patients.Methods This study was a prospective study.A total of 107 colorectal cancer patients diagnosed and treated with oxaliplatin in Henan Provincial People’s Hospital from March 2021 to February 2023 were selected as the study objects.The occurrence of neurotoxicity in patients was counted.Patients with oxaliplatin related neurotoxicity were included in the occurrence group,and the others were included in the non-occurrence group.The data required for the study were counted and recorded,and the influencing factors of oxaliplatin related neurotoxicity in patients with colorectal cancer were analyzed.Results Among the 107 patients with colorectal cancer,86 cases experienced neurotoxicity after oxaliplatin therapy,with an incidence of 80.37%(86/107).The proportions of patients with tumor node metastasis(TNM)stage Ⅲ,diabetes,peripheral venous infusion in the occurrence group were higher than those in the non-occurrence group,moreover,the cumulative dose and infusion speed of oxaliplatin of the occurrence group were higher than those of the non-occurrence group(P<0.05).The analysis results of logistic regression model showed that TNM stage,diabetes,infusion mode,cumulative dose of oxaliplatin,and infusion speed might be the risk factors for the occurrence of oxaliplatin related neurotoxicity in colorectal cancer patients(all OR>1,all P<0.05).Conclusions TNM stage,diabetes,drug infusion mode,cumulative dose and infusion speed may be risk factors of oxaliplatin related neurotoxicity in colorectal cancer patients after treatment.
作者
刘林莉
李珍
阎蕾蕾
杜倩
Liu Linli;Li Zhen;Yan Leilei;Du Qian(Cancer Center,Henan Provincial People's Hospital,People's Hospital of Zhengzhou University,People's Hospital of Henan University,Henan Provincial Key Laboratory of Nursing Medicine,Zhengzhou 450000,China;Ward Ⅰ,ICU Center,Henan Provincial People's Hospital,Zhengzhou 450000,China)
出处
《中国实用医刊》
2024年第15期30-33,共4页
Chinese Journal of Practical Medicine
基金
河南省医学科技攻关计划省部共建重点项目(SBGJ202102002)。
关键词
结直肠癌
奥沙利铂
神经毒性
肿瘤
Colorectal neoplasms
Oxaliplatin
Neurotoxicity
Tumor
