摘要
目的探讨柴芩麻膏汤联合血必净注射液治疗重症肺炎患者的临床疗效。方法选取2019年1月—2022年1月期间郑州大学附属郑州中心医院收治的重症肺炎合并Ⅱ型呼吸衰竭患者70例,按随机数字表法分为对照组和研究组,每组各35例。对照组给予常规治疗,研究组在对照组基础上给予柴芩麻膏汤联合血必净注射液治疗。两组患者均治疗7 d。观察比较两组患者临床疗效、不良反应发生率,治疗前后中医证候积分,急性生理与慢性健康评分(APACHEⅡ),血清学指标[二胺氧化酶(Diamine oxidase,DAO)、D-乳酸(D-Lactic acid,D-LA)、肿瘤坏死因子-α(Tumor necrosis factor-alpha,TNF-α)、降钙素原(Procalcitonin,PCT)及白细胞介素-6(Interleukin-6,IL-6)]、肺功能指标[第1秒用力呼气容积(Lst forced expiratory volume,FEV1)、最大呼气流量(Peak expiratory flow,PEF)、用力肺活量(Forced vital capacity,FVC)]水平。结果治疗后研究组临床总有效率91.43%(32/35)明显高于对照组71.43%(25/35),差异有统计学意义(P<0.05)。治疗后两组患者中医证候积分及APACHEⅡ评分均较治疗前降低,差异有统计学意义(P<0.05);且研究组中医证候积分及APACHEⅡ评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者DAO、D-LA、TNF-α、PCT及IL-6水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组血清学指标明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者FVC、FEV1及PEF水平均较治疗前升高,差异有统计学意义(P<0.05);且研究组肺功能指标明显高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论柴芩麻膏汤联合血必净遵循肺肠同治理论,能有效治疗重症肺炎,改善症状及病情,减轻炎症反应,改善肠黏膜屏障功能,且安全性可靠。
Objective To investigate the clinical efficacy of Chaiqin Magao decoction combined with Xuebijing injection in treating patients with severe pneumonia.Methods A total of 70 patients with severe pneumonia combined with type II respiratory failure admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2019 to January 2022 were selected as the study subjects.They were divided into a control group and a study group using the random number table method,with 35 patients in each group.The control group was given conventional treatment,while the study group was given Chaiqin Magao decoction combined with Xuebijing injection based on the control group.Both groups were treated for 7 days.The clinical efficacy,incidence of adverse reactions,and traditional Chinese medicine(TCM)syndrome scores,Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ)scores,serum markers[diamine oxidase(DAO),D-lactic acid(D-LA),tumor necrosis factor-α(TNF-α),procalcitonin(PCT)and interleukin-6(IL-6)],and lung function indicators[first-second forced expiratory volume(FEV1),peak expiratory flow(PEF),forced vital capacity(FVC)]were observed and compared between the two groups before and after treatment.Results After treatment,the total clinical effective rate was significantly higher in the study group(91.43%,32/35)than in the control group(71.43%,25/35),with a statistically significant difference(P<0.05).TCM syndrome scores and APACHEⅡscores in both groups were significantly lower after treatment compared to before treatment,with a statistically significant difference(P<0.05);these scores were significantly lower in the study group than in the control group,with a statistically significant difference(P<0.05).DAO,D-LA,TNF-α,PCT and IL-6 levels in both groups were significantly lower after treatment compared to before treatment,with a statistically significant difference(P<0.05);these serum markers were significantly lower in the study group than in the control group,with a statistically significant differe
作者
郅红蕾
何莹莹
运苛政
孙捷
赵雅彬
ZHI Hong-lei;HE Ying-ying;YUN Ke-zheng;SUN Jie;ZHAO Ya-bin(Department of Emergency Medicine,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou Henan 450000;Department of Respiratory Medicine,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou Henan 450000)
出处
《世界中西医结合杂志》
2024年第8期1587-1591,共5页
World Journal of Integrated Traditional and Western Medicine
基金
河南省教育厅重点科研项目(20A360010)。
关键词
肺肠同治理论
柴芩麻膏汤
血必净注射液
重症肺炎
Theory of Simultaneous Treatment of Lung and Intestine
Chaiqin Magao Decoction
Xuebijing Injection
Severe Pneumonia
