摘要
目的基于三证三法、菌毒炎同治理论探讨血必净注射液在治疗重症肺炎感染患者中的临床疗效和安全性。方法选取2021年1月—2023年12月期间淮南东方医院集团总医院收治的热毒炽盛证合并瘀毒内阻证重症肺炎患者72例,采用随机数字表法分为对照组和治疗组,每组各36例。对照组给予常规西医治疗,包括抗感染治疗、机械通气、化痰、营养治疗等。治疗组在对照组基础上联合使用血必净注射液,均治疗10 d。观察比较两组患者临床有效率、不良反应,治疗前后中医证候评分、临床肺部感染评分(Clinical pulmonary infection score,CPIS)、生化指标[C反应蛋白(C-reactive protein,CRP)、降钙素原(Procalcitonin,PCT)]、血气分析[动脉血氧饱和度(Oxygen saturation in arterial blood,SaO_(2))、(Partial pressure of oxygen in arterial blood,PaO_(2))]及相关血清炎症因子[肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)、白细胞介素-8(Interleukin-8,IL-8)]水平。结果治疗后两组患者CPIS和中医证候评分均较治疗前明显降低,差异有统计学意义(P<0.01);且治疗组CPIS评分低于对照组,差异有统计学意义(P<0.05);治疗组中医证候评分与对照组比较,差异无统计学意义(P>0.05)。治疗后两组患者感染生化指标CRP,PCT水平较治疗前明显降低,血气分析指标SaO_(2)水平较治疗前升高,差异有统计学意义(P<0.01);且治疗组CRP指数水平低于对照组,SaO_(2)水平高于对照组,差异有统计学意义(P<0.05,P<0.01)。治疗后两组患者血清炎症因子IL-6、IL-8和TNF-α水平较治疗前明显降低,差异有统计学意义(P<0.01);且治疗组血清炎症因子水平低于对照组,差异有统计学意义(P<0.05)。治疗后治疗组临床总有效率91.67%(33/36)高于对照组77.78%(28/36),差异有统计学意义(P<0.05)。治疗组不良反应事件发生率高于对照组,但差异无统计学意义(P>0.05)。结论血必�
Objective To explore the clinical efficacy and safety of Xuebijing Injection in the treatment of patients with severe pneumonia infection based on the theory of“simultaneous treatment of bacteria,viruses,and inflammation”and the“three methods for three syndromes”approach.Methods Seventy-two patients with severe pneumonia presenting with the syndrome of heat toxin exuberance combined with internal obstruction of blood stasis toxin syndrome,admitted to Eastern Huainan Hospital Group General Hospital from January 2021 to December 2023,were selected and randomly divided into a control group and a treatment group according to a random number table,with 36 cases in each group.The control group received conventional Western medical treatment,including anti-infective therapy,mechanical ventilation,phlegm resolving,and nutritional support.The treatment group received Xuebijing Injection in addition to the treatment protocol of the control group,with both groups treated for 10 days.Clinical efficacy,adverse reactions,traditional Chinese medicine(TCM)syndrome scores,clinical pulmonary infection score(CPIS),biochemical markers[C-reactive protein(CRP),procalcitonin(PCT)],blood gas analysis[oxygen saturation in arterial blood(SaO_(2)),partial pressure of oxygen in arterial blood(PaO_(2))],and serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)]of the two groups were observed and compared before and after treatment.Results After treatment,both groups showed a significant reduction in CPIS and TCM syndrome scores compared to those before treatment(P<0.01).The CPIS score in the treatment group was lower than that in the control group(P<0.05).However,there was no statistically significant difference in TCM syndrome scores between the treatment and control groups(P>0.05).The levels of infection biochemical markers CRP and PCT in both groups were significantly reduced compared to those before treatment,while the SaO_(2) level in blood gas analysis was significantly increased(P<
作者
桂永梅
倪荣萍
GUI Yong-mei;Ni Rong-ping(Department of Respiratory Medicine,Eastern Huainan Hospital Group General Hospital,Huainan Anhui 232000;Department of Respiratory Medicine,Suzhou Jingdongfang Hospital,Suzhou Jiangsu 215200)
出处
《世界中西医结合杂志》
2024年第8期1566-1570,共5页
World Journal of Integrated Traditional and Western Medicine
关键词
三证三法
菌毒炎同治
血必净注射液
重症肺炎
Three Methods for Three Syndromes
Simultaneous Treatment of“Bacteria,Viruses,and Inflammation”
Xuebijing Injection
Severe Pneumonia