摘要
目的探讨戈舍瑞林联合腹腔镜下子宫肌瘤剔除术治疗子宫肌瘤的效果及对新生血管的影响。方法随机选取2020年7月—2023年7月兰州新区第一人民医院收治的100例子宫肌瘤患者为研究对象。根据是否使用戈舍瑞林将其分为两组,各50例。两种患者均进行腹腔镜下子宫肌瘤剔除术,观察组在术后给予戈舍瑞林治疗。对比两组患者的子宫微循环状态指标、卵巢功能指标和新生血管指标的差异。结果治疗后,两组患者的子宫动脉阻力指数、脉动指数均升高,且观察组高于对照组,差异有统计学意义(P均<0.05)。两组患者的收缩期峰值血流速度低于治疗前,差异有统计学意义(P<0.05),且观察组(37.08±4.14)cm/s低于对照组的(45.85±6.16)cm/s,差异有统计学意义(t=7.122,P<0.05)。两组患者的雌二醇、垂体泌乳素、促卵泡生成激素、促黄体生成素等卵巢功能指标均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。两组患者的血管内皮生长因子、微血管密度、表皮生长因子等新生血管指标均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。结论戈舍瑞林联合腹腔镜下子宫肌瘤剔除术治疗子宫肌瘤能有效改善子宫微循环状态、降低卵巢功能指标及新生血管指标水平,表明该联合治疗策略不仅对子宫肌瘤的治疗效果较好,同时也对减缓肌瘤的生长和血管新生具有积极作用。
Objective To explore the impact of combining Goserelin with laparoscopic hysteromyomectomy on the treatment of uterine myoma and its influence on the neovascularization.Methods A total of 100 patients with uterine myoma admitted to the First People's Hospital of Lanzhou New Area from July 2020 to July 2023 were randomly se-lected as the research objects.According to whether to use goserelin,they were divided into two groups,50 cases in each group.Both patients underwent laparoscopic hysteromyomectomy,and the observation group was treated with gos-erelin after surgery.The differences of uterine microcirculation state index,ovarian function index and neovasculariza-tion index between the two groups were compared.Results After treatment,the uterine artery resistance index and pul-satility index of the two groups increased,and those in the observation group were higher than the control group,the differences were statistically significant(all P<0.05).The peak systolic velocity of the two groups was lower than that before treatment,the difference was statistically significant(P<0.05),and the observation group's(37.08±4.14)cm/s was lower than the control group's(45.85±6.16)cm/s,the difference was statistically significant(t=7.122,P<0.05).The estradiol,prolactin,follicle stimulating hormone and luteinizing hormone in the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(all P<0.05).The vascular endothelial growth factor,microvessel density and epidermal growth factor in the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(all P<0.05).Conclusion Goscherilin combined with laparoscopic hysteromyomectomy can effectively improve the state of uterine microcirculation,reduce the levels of ovarian function indicators and neovascularization indicators,indicating that this combined treatment strategy not only has a better impact on the treatment of uterine
作者
常霞丽
姜亮
CHANG Xiali;JIANG Liang(Department of Obstetrics and Gynecology,The First People's Hospital of Lanzhou New Area,Lanzhou 730000,Gansu,)
出处
《中外医疗》
2024年第23期103-107,共5页
China & Foreign Medical Treatment
