摘要
目的探讨二氧化碳(carbon dioxide,CO_(2))激光治疗女性宫颈低级别上皮内病变(low grade squamous in-traepithelial lesions,LSIL)的效果及其对患者性功能的影响。方法方便选取2021年1月—2023年4月泰州市第二人民医院妇科收治的85例LSIL合并人乳头瘤病毒(human papillomavirus,HPV)感染患者为研究对象,按照治疗方式不同分为两组。对照组(40例)采用重组人干扰素-α2b(recombinant human interferonα2b,IFN-α2b)治疗,观察组(45例)在对照组的基础上采用CO_(2)激光治疗,两组均随访6个月。比较两组HPV感染转阴情况、治疗效果及性功能等情况。结果观察组治疗后3个月、6个月的治愈率高于对照组,差异有统计学意义(P均<0.05);观察组治疗后6个月的复发率为5.00%(2/40),低于对照组的21.43%(6/28),差异有统计学意义(χ^(2)=4.282,P<0.05);观察组治疗后3个月、6个月的HPV转阴率高于对照组,差异有统计学意义(P均<0.05)。观察组治疗后6个月的HPV载量为(1.35±0.38)copies/mL,低于对照组的(1.89±0.42)copies/mL,差异有统计学意义(P<0.05)。治疗后6个月两组的性生活丧失率、女性性功能指数调查量表评分对比,差异无统计学意义(P均>0.05)。结论CO_(2)激光治疗能够提高女性LSIL合并HPV患者的治疗效果及HPV转阴率,且对患者的性功能无显著影响。
Objective To investigate the effect of carbon dioxide(CO_(2))laser treatment on low grade squamous intraepi-thelial lesions(LSIL)and their effects on sexual function.Methods 85 patients with LSIL combined with human papil-lomavirus(HPV)infection admitted to the gynecology department of Taizhou Second People's Hospital from January 2021 to April 2023 were conveniently selected as the study object,and were divided into two groups according to dif-ferent treatment methods.Control group(n=40)was treated with recombinant human interferonα2b(IFN-α2b),obser-vation group(n=45)was treated with CO_(2) laser on the basis of control group,both groups were followed up for 6 months.The HPV infection turning negative,treatment effect and sexual function were compared between the two groups.Results The cure rate of the observation group at 3 months and 6 months after treatment was higher than that of the control group,the differences were statistically significant(both P<0.05).The recurrence rate after 6 months of treatment group was 5.00%(2/40),which was lower than 21.43%(6/28)of the control group,and the difference was statistically significant(χ^(2)=4.282,P<0.05).The negative HPV conversion rate in the observation group at 3 months and 6 months after treatment were higher than those in the control group,and the differences were statistically signifi-cant(both P<0.05).The HPV load of the observation group at 6 months after treatment was(1.35±0.38)copies/mL,lower than that of the control group(1.89±0.42)copies/mL,and the difference was statistically significant(P<0.05).There was no significant difference in the loss rate of sexual life and the score of the female sexual function index sur-vey scale between the two groups at 6 months after treatment(both P>0.05).Conclusion CO_(2) laser therapy can im-prove the therapeutic effect and negative conversion rate of HPV in female LSIL patients with HPV,and has no signifi-cant effect on the sexual function of the patients.
作者
韩春霞
冯兰兰
HAN Chunxia;FENG Lanlan(Department of Gynecology,Taizhou Second People's Hospital,Taizhou 225511,Jiangsu,China)
出处
《中外医疗》
2024年第23期31-34,共4页
China & Foreign Medical Treatment
关键词
CO_(2)激光
女性
宫颈低级别上皮内病变
人乳头瘤病毒转阴率
性功能
CO_(2)laser
Women
Low grade squamous intraepithelial lesions
Human papillomavirus negative conversion rate
Sexual function
