摘要
目的探讨氨氯地平联合舍曲林治疗卒中后中重度抑郁(PSD)患者疗效及对降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)的影响。方法选取2022年6月至2023年11月于浙江省温州市第七人民医院精神科就诊的卒中后抑郁(PSD)患者80例,根据随机数字表法分为对照组(舍曲林口服治疗40例)、观察组(氨氯地平联合舍曲林口服治疗40例)。对比2组的临床疗效,并观察比较其抑郁、神经功能改善情况以及相关血清因子的变化。结果观察组临床疗效总有效率较对照组高(P<0.05);治疗1、2、3个月后,观察组抑郁症状抑郁筛查量表(PHQ-9)评分较对照组低(P<0.05),观察组神经功能美国国立卫生研究院卒中量表(NIHSS)评分较对照组低(P<0.05),治疗3个月后,观察组PCT、CRP、IL-6水平较对照组低(P<0.05)。结论氨氯地平联合舍曲林治疗卒中后中重度PSD患者的疗效佳,具有改善抑郁症状及神经功能的作用,同时可降低炎症标志物PCT、CRP、IL-6的水平。
Objective To explore the effects of amlodipine combined with sertraline in the treatment of moderate to severe depression(PSD)after stroke and its impact on calcitonin(PCT),C-reactive protein(CRP),and interleukin-6(IL-6).Methods A total of 80 patients with post-stroke depression(PSD)who were treated in the Department of Psychiatry at the Seventh People′s Hospital of Wenzhou City from June 2022 to November 2023 were selected.According to the random number table method,the participants were randomly divided into a con-trol group(treated with oral sertraline,n=40)and an observation group(treated with amlodipine combined with oral sertraline,n=40).The clinical efficacy of the two groups was compared,and the changes in depression,neurologi-cal function improvement,and related serum factors were observed and compared.Results The total effective rate of clinical efficacy in the observation group was significantly higher than that in the control group(P<0.05).After 1,2,and 3 months of treatment,the depression symptom(PHQ-9)score in the observation group was significantly lower than that in the control group(P<0.05);The neurological function(NIHSS)score in the observation group was significantly lower than that in the control group(P<0.05).After 3 months of treatment,the levels of PCT,CRP,and IL-6 in the observation group were significantly lower than those in the control group(P<0.05).Conclusion The combination of amlodipine and sertraline has a good therapeutic effect on patients with moderate to severe PSD after stroke,which can improve depressive symptoms and neurological function,and at the same time reduce the levels of inflammatory markers PCT,CRP,and IL-6.
作者
焦然
黄建杰
吴联
Jiao Ran;Huang Jianjie;Wu Lian(Spiritual Comprehensive Ward 2,Seventh People′s Hospital of Wenzhou CityWenzhou,Zhejiang 325000,China)
出处
《中国药物与临床》
CAS
2024年第17期1121-1125,共5页
Chinese Remedies & Clinics
基金
浙江省温州市科研项目(Y20220834)。
关键词
氨氯地平
舍曲林
卒中
抑郁
炎症因子
Amlodipine
Shequlin
Stroke
Depression
Inflammatory factors
