摘要
目的探讨中耳积液中白介素-10(IL-10)、白细胞三稀D4(LTD4)表达与分泌性中耳炎患者术后咽鼓管阻塞的关系。方法回顾性分析,收集信阳职业技术学院附属医院2019年1月至2022年12月行手术治疗的120例分泌性中耳炎患者的临床资料,所有患者术前均进行中耳积液中IL-10、LTD4检查,均完成术后为期6个月的随访。依据患者术后咽鼓管阻塞发生情况进行分组,将随访期间31例并发咽鼓管阻塞的患者临床资料纳入发生组,将其余89例未并发咽鼓管阻塞的患者临床资料纳入未发生组。查阅并记录研究所需资料,将可能的因素纳入,经多因素logistic回归分析检验分泌性中耳炎患者术后咽鼓管阻塞的影响因素,分析中耳积液中IL-10、LTD4表达与分泌性中耳炎患者术后咽鼓管阻塞的关系。结果单因素分析发现,发生组中耳积液中IL-10、LTD4水平高于未发生组,咽鼓管功能不良占比高于未发生组,差异有统计学意义(P<0.05)。经多因素logistic分析结果显示,中耳积液中IL-10、LTD4水平高、咽鼓管功能不良是分泌性中耳炎患者术后并发咽鼓管阻塞的危险因素(OR>1,P<0.05)。结论中耳积液中IL-10、LTD4表达与分泌性中耳炎患者术后咽鼓管阻塞具有密切关系,二者水平高表达是分泌性中耳炎患者术后并发咽鼓管阻塞的危险因素。
Objective To investigate the relationship between the expression of interleukin-10(IL-10)and leukotriene D4(LTD4)in middle ear effusion and postoperative eustachian tube obstruction in patients with secretory otitis media.Methods Retrospective analysis was conducted to collect clinical data of 120 patients with secretory otitis media who underwent surgical treatment at the Affiliated Hospital of Xinyang Vocational and Technical College from January 2019 to December 2022.All patients underwent preoperative examination for IL-10 and LTD4 in the middle ear effusion,and all completed a 6-month follow-up after surgery.According to the occurrence of postoperative eustachian tube obstruction in patients,clinical data of 31 patients with concurrent eustachian tube obstruction during the follow-up period were included in the occurrence group,and clinical data of the remaining 89 patients without concurrent eustachian tube obstruction were included in the non occurrence group.The data required for the study were reviewed and recorded,and the possible factors were included.Multivariate logistic regression analysis was used to test the influencing factors of postoperative eustachian tube obstruction in patients with secretory otitis media.The relationships between the expression of IL-10 and LTD4 in middle ear effusion and postoperative eustachian tube obstruction in patients with secretory otitis media were analyzed.Results The univariate analysis showed that the levels of IL-10 and LTD4 in the middle ear effusion in the occurrence group were higher than those in the non occurrence group,and the proportion of eustachian tube dysfunction was higher than that in the non occurrence group,with a statistical significant difference(P<0.05).The results of multivariate logistic analysis showed that high levels of IL-10 and LTD4 in middle ear effusion,as well as poor eustachian tube function,were risk factors for postoperative eustachian tube obstruction in patients with secretory otitis media(OR>1,P<0.05).Conclusion The expression
作者
李明全
LI Mingquan(Department of Otolaryngology,the Affiliated Hospital of Xinyang Vocational and Technical College,Xinyang 464000,China)
出处
《河南医学研究》
CAS
2024年第18期3353-3357,共5页
Henan Medical Research
