摘要
幽门螺杆菌是一种能够在胃黏膜中定植的革兰氏阴性杆菌。幽门螺杆菌可诱导胃部产生癌症相关成纤维细胞。幽门螺杆菌的毒力因子以及癌症相关成纤维细胞可引发上皮-间质转化,导致局部炎症、胃黏膜损伤和慢性胃炎的发生。本文重点综述了幽门螺杆菌感染后癌症相关成纤维细胞介导的胃部上皮-间质转化的分子机制,为未来治疗幽门螺杆菌感染相关性胃癌的潜在分子靶点和策略提供新的见解。
Helicobacter pylori(Hp)is a Gram-negative bacterium that colonizes in the gastric mucosa.Hp induces the production of cancer-associated fibroblasts(CAF)in the stomach.The virulence factors of Hp and CAF trigger epithelial-mesenchymal transition(EMT),leading to local inflammation,damage to the gastric mucosa,and the occurrence of chronic gastritis.Here,we summarize the molecular mechanisms of CAF mediated gastric EMT after Hp infection,providing new insights into potential molecular targets and strategies for the future treatment of Hp infection associated gastric cancer.
作者
李逸粼
郑丽飞
LI Yi-Lin;ZHENG Li-Fei(School of Basic Medical Sciences,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China;Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China)
出处
《生理学报》
CAS
CSCD
北大核心
2024年第4期547-560,共14页
Acta Physiologica Sinica
基金
supported by Beijing Municipal Natural Science Foundation(No.5172006)
Capital Medical University 2023 Long Term Mentor Program(No.CXZDS2023031).
