摘要
目的探讨老年T2DM患者肌少症与血尿酸(_(SUA))的相关性。方法选取2022年1月至2023年9月于新疆医科大学第一附属医院内分泌科住院治疗的T2DM患者522例,根据是否合并肌少症分为单纯T2DM组(n=431)和T2DM合并肌少症组(Sar,n=91)。按照_(BMI)四分位数分为Q1_(BMI)组(≤23.70 kg/m^(2))、Q2_(BMI)组(23.80~26.10 kg/m^(2))、Q3_(BMI)组(26.20~29.00 kg/m^(2))、Q4_(BMI)组(>29.00 kg/m^(2)),另按照_(SUA)四分位数分为Q1_(SUA)组(≤269.00μmol/L)、Q2_(SUA)组(269.01~313.00μmol/L)、Q3_(SUA)组(313.01~363.00μmol/L)、Q4_(SUA)组(>363.00μmol/L)。比较各组一般资料及生化指标,Pearson相关分析四肢骨骼肌质量指数(ASMI)与其他指标的相关性,Logistic回归分析老年T2DM合并患肌少症的影响因素。结果Sar组年龄、Hb A1c、2 hPG高于T2DM组,_(BMI)、FC-P、_(SUA)、ASMI、握力、步速低于T2DM组(P<0.05)。Pearson相关分析显示,ASMI与_(SUA)呈正相关(P<0.05)。Logistic回归分析显示,校正年龄、_(BMI)、2 hPG后,_(SUA)仍是老年T2DM合并肌少症的影响因素。Q1_(BMI)、Q2_(BMI)组肌少症发生风险高于Q4_(BMI)组(P<0.05),Q1_(SUA)组肌少症发生风险高于Q4_(SUA)组(P<0.05)。结论_(SUA)是老年T2DM合并肌少症的保护因素,_(SUA)偏低的老年T2DM患者更易发生肌少症。
Objective To evaluated the serum uric acid(_(SUA))level in elderly patients with type 2 diabetes mellitus(T2DM)and sarcopenia,and to explore the relationship between _(SUA) and T2DM with sarcopenia.Methods A total of 522 hospitalized patients with T2DM who were admitted to the Department of Endocrinology,The First Affiliated Hospital of Xinjiang Medical University were enrolled in this study from January 2022 to September 2023.All the patients were divided into T2DM without sarcopenia group(n=431)and T2DM with sarcopenia group(Sar,n=91)according to the presence of sarcopenia.In addition,participants were divided into four groups:Q1_(BMI)(≤23.70 kg/m^(2)),Q2_(BMI)(23.80~26.10 kg/m^(2)),Q3_(BMI)(26.20~29.00 kg/m^(2)),and Q4_(BMI)(>29.00 kg/m^(2))according to _(BMI) quartiles.Besides,depending on _(SUA) quartiles,they were divided intofour groups Q1_(SUA)(≤269.00μmol/L),Q2_(SUA)(269.01~313.00μmol/L),Q3_(SUA)(313.01~363.00μmol/L),and Q4_(SUA)(>363.00μmol/L).The clinical data and biochemical indexes were compared between groups.Pearson correlation analysis was used to investigate the correlation between ASMI and other indexes.The influencing factors for sarcopenia in elderly T2DM were analyzed by logistic regression.Results The age,HbA1c,and 2 hPG levels were higher,while the _(BMI),FC-P,_(SUA),ASMI,grip strength,and gait speed were lower in the Sar group than in the T2DM group(P<0.05).Pearson correlation analysis showed that _(SUA) was positively correlated with ASMI(P<0.05).Logistic regression analysis revealed that _(SUA) was still the influencing factor for sarcopenia after adjusting for age,_(BMI),and 2 hPG.The risk of sarcopenia was higher in the Q1_(BMI) and Q2 _(BMI) groups than in the Q4_(BMI) group(P<0.05),and the risk of sarcopenia was higher in the Q1_(SUA) group than in the Q4_(SUA) group(P<0.05).Conclusion _(SUA) is a protective factor in elderly T2DM patients with sarcopenia.Elderly T2DM patients with low _(SUA) are prone to develop sarcopenia.
作者
顾思雯
徐静
樊勇
GU Siwen;XU Jing;FAN Yong(Department of Endocrinology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2024年第8期613-616,共4页
Chinese Journal of Diabetes
基金
新疆医科大学第一附属医院青年科研起航专项基金(2022YFY-QNRC-11)。
关键词
糖尿病
2型
肌少症
血尿酸
影响因素
Diabetes mellitus,type 2
Sarcopenia
Serum uric acid
Influencing factors
