摘要
目的:探讨阿替普酶注射液联合常规治疗在急性脑梗死患者治疗中的效果。方法:选取2023年3月—2024年3月本院诊治的急性脑梗死患者124例作为研究对象,根据随机信封抽签原则将患者分为阿替普酶组62例与对照组62例。对照组给予尿激酶联合常规治疗,阿替普酶组给予阿替普酶注射液联合常规治疗,比较两组治疗效果、美国国立卫生研究院卒中量表(NIHSS)评分、脑大动脉脑血流量、血清同型半胱氨酸含量。结果:所有患者都顺利完成治疗,无发生严重并发症,治疗14 d后阿替普酶组有效率为98.39%,高于对照组的88.71%(P<0.05);阿替普酶组NIHSS评分低于对照组(P<0.05);阿替普酶组脑动脉脑血流量高于对照组(P<0.05);阿替普酶组血清同型半胱氨酸含量低于对照组(P<0.05)。结论:阿替普酶注射液联合常规治疗在急性脑梗死患者治疗中的效果良好,可降低神经功能损失程度,提高患者脑大动脉脑血流量,降低血清同型半胱氨酸含量,改善患者预后。
Objective:To investigate the effect of alteplase injection combined with conventional therapy in the treatment of patients with acute cerebral infarction.Methods:A total of 124 patients with acute cerebral infarction diagnosed and treated in our hospital from March 2023 to March 2024 were selected as the research objects.According to the principle of random envelope drawing,the patients were divided into alteplase group(62 cases)and control group(62 cases).The control group was given urokinase combined with routine treatment,and the alteplase group was given alteplase injection combined with routine treatment.The therapeutic effect,National Institutes of Health Stroke Scale(NIHSS)score,cerebral blood flow of cerebral artery and serum homocysteine content were compared between the two groups.Results:All patients successfully completed the treatment without serious complications.After 14 days of treatment,the effective rate of alteplase group was 98.39%,which was higher than 88.71%of control group(P<0.05).The NIHSS score of the alteplase group was lower than that of the control group(P<0.05).The cerebral blood flow in the alteplase group was higher than that in the control group(P<0.05).The serum homocysteine content in the alteplase group was lower than that in the control group(P<0.05).Conclusion:Alteplase injection combined with routine treatment has a good effect in the treatment of patients with acute cerebral infarction.It can reduce the degree of neurological loss,improve the cerebral blood flow of cerebral artery,reduce the content of serum homocysteine and improve the prognosis of patients.
作者
睢志向
余清超
SUI Zhixiang;YU Qingchao(Department of Neurology,Ningling County People’s Hospital,Ningling 476700,Henan,China)
出处
《中国药物滥用防治杂志》
CAS
2024年第8期1469-1471,1486,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
国家卫生健康委“十三五”重大慢性非传染性疾病防控研究(编号:2017YFC1308202)。
关键词
阿替普酶注射液
脑梗死
脑大动脉脑血流量
血清同型半胱氨酸含量
Alteplase injection
Cerebral infarction
Cerebral blood flow of cerebral artery
Serum homocysteine content
