摘要
目的探讨对寻常痤疮(湿热蕴结型)患者实施自拟清热解毒汤联合针灸治疗的效果及对其皮肤屏障功能的影响。方法选择湿热蕴结型寻常痤疮患者80例作为研究对象,以随机数字表法分为对照组和观察组,各40例。对照组以盐酸米诺环素胶囊+莫匹罗星软膏外涂治疗,观察组给予自拟清热解毒汤联合针灸治疗。对比两组患者疗效、皮肤屏障功能及中医证候积分。结果观察组治疗总有效率为95.00%,较对照组的77.50%更高(P<0.05)。疗程结束后,两组患者中医证候积分均较治疗前改善,且观察组疗程结束后的皮疹脓疱、面部油腻、口臭、尿黄积分分别为(1.07±0.13)、(1.07±0.03)、(1.15±0.24)、(1.01±0.13)分,均低于对照组的(2.21±0.58)、(2.14±0.24)、(2.08±0.27)、(2.19±0.58)分(P<0.05)。疗程结束后,两组患者皮肤屏障功能均较治疗前得到改善,且观察组的经皮水分丢失量(15.84±0.32)g/(cm^(2)·h)、皮肤粘脱蛋白质含量(30.24±1.64)μg均显著低于对照组的(20.53±1.52)g/(cm^(2)·h)、(36.45±2.49)μg,而角质层含水量(46.84±4.24)AU显著高于对照组的(37.46±3.78)AU(P<0.05)。结论以自拟清热解毒汤结合针灸治疗湿热蕴结型寻常痤疮的疗效肯定,可有效改善临床症状,保护患者的皮肤屏障功能,值得应用。
Objective To explore the effect of self-made Qingre Jiedu Decoction combined with acupuncture and moxibustion for patients with acne vulgaris(damp-heat accumulation type),and its influence on their skin barrier function.Methods 80 patients with patients with acne vulgaris of damp-heat accumulation type were selected as the subjects of this study.They were divided into a control group and an observation group by random number table,each consisting of 40 cases.The control group was treated with minocycline hydrochloride capsules+mupirocin ointment,and the observation group was treated with self-made Qingre Jiedu Decoction and acupuncture and moxibustion.The efficacy,skin barrier function,and traditional Chinese medicine syndrome score of the two groups were compared.Results The total effective rate of the observation group was 95.00%,which was higher than 77.50%of the control group(P<0.05).After the treatment,the traditional Chinese medicine syndrome score was improved in both groups;the scores of rash and pustules,facial greasy,halitosis and urine yellow in the observation group were(1.07±0.13),(1.07±0.03),(1.15±0.24)and(1.01±0.13)points,which were lower than(2.21±0.58),(2.14±0.24),(2.08±0.27)and(2.19±0.58)points in the control group(P<0.05).After the treatment,the skin barrier function was improved in both groups compared to that before treatment;the observation group had transdermal water loss of(15.84±0.32)g/(cm2·h)and skin adhesion protein content of(30.24±1.64)μg,which were significantly lower than(20.53±1.52)g/(cm2·h)and(36.45±2.49)μg in the control group;the water content of stratum corneum of(46.84±4.24)AU in the observation group was significantly higher than(37.46±3.78)AU in the control group(P<0.05).Conclusion The combination of self-made Qingre Jiedu Decoction and acupuncture and moxibustion is effective in the treatment of acne vulgaris of damp-heat accumulation type,which can effectively improve the clinical symptoms and protect the skin barrier function of patients,and is worthy of
作者
周泉宇
塔娜
张一宁
张海龙
ZHOU Quan-yu;Tana;ZHANG Yi-ning(Department of Traditional Chinese Medicine,Foshan Fifth People's Hospital,Foshan 528000,China)
出处
《中国实用医药》
2024年第17期149-152,共4页
China Practical Medicine
关键词
自拟清热解毒汤
针灸
湿热蕴结型
寻常痤疮
皮肤屏障功能
Self-made Qingre Jiedu Decoction
Acupuncture and moxibustion
Damp-heat accumulation type
Acne vulgaris
Skin barrier function
