摘要
目的探讨清热散结胶囊联合开喉剑喷雾剂治疗对反流性咽喉炎声嘶症状以及反流症状指数评分量表(reflux symptom index,RSI)评分和反流体征指数评分(reflux findings score,RFS)的影响。方法选取丽水市人民医院2020年1月—2022年1月收治的90例反流性咽喉炎患者作为研究对象,按照随机数字表法分为观察组45例(给予清热散结胶囊联合开喉剑喷雾剂治疗)和对照组45例(给予清热散结胶囊治疗)。观察治疗后的临床疗效,症状积分,胃蛋白酶水平,炎症因子水平,RSI、RFS评分。结果治疗后,观察组患者的显效率为60.00%(27/45),高于对照组患者的35.56%(16/45)(P<0.05)。治疗后,观察组咳嗽、声嘶、吞咽困难、反酸烧心、咽喉黏滞等症状积分均低于对照组患者(P<0.05)。治疗前,两组患者的胃蛋白酶水平比较,差异无统计学意义(P>0.05);治疗后3 d、7 d,观察组患者的胃蛋白酶水平分别低于对照组患者(P<0.05)。治疗前,两组患者白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)值比较,差异无统计学意义(P>0.05);治疗后7 d,观察组患者的IL-6、TNF-α值均低于对照组患者(P<0.05)。治疗前,两组患者RSI评分和RFS评分比较,差异无统计学意义(P>0.05);治疗后7 d,观察组患者的RSI评分和RFS评分均低于对照组患者(P<0.05)。结论清热散结胶囊联合开喉剑喷雾剂能够提高反流性咽喉炎患者的临床疗效,降低患者症状积分,改善胃蛋白酶水平,降低炎症因子水平以及改善反流症状与反流体征,值得临床推广。
Objective To investigate the effects of Qingre Sanjie Capsule(清热散结胶囊)combined with Kaihoujian Spray(开喉剑喷雾剂)on hoarseness symptoms,reflux symptom index(RSI)and reflux findings score(RFS)of reflux laryngitis.Methods Ninety patients with reflux pharyngitis admitted to the hospital from January 2020 to January 2022 were selected as research objects,and were divided into observation group(45 cases received Qingre Sanjie Capsule combined with Kaihoujian Spray)and control group(45 cases received Qingre Sanjie Capsule)according to random number table method.The clinical efficacy,symptom scores,pepsin level,inflammatory factor levels,RSI and RFS scores were observed after treatment.Results After treatment,the significant efficiency of the observation group was 60.00%(27/45),higher than that of the control group(35.56%,16/45)(P<0.05).After treatment,the scores of cough,hoarseness,dysphagia,acid reflux heartburn,throat viscosity and other symptoms in the observation group were lower than those in the control group(P<0.05).Before treatment,the level of pepsin in two groups was not significant(P>0.05).At 3 d and 7 d after treatment,the level of pepsin in the observation group was lower than that in the control group(P<0.05).Before treatment,the values of interleukin-6,(IL-6)and tumor necrosis factor-α(TNF-α)has no significance between two groups(P>0.05).At 7 d after treatment,the values of IL-6 and TNF-αin the observation group were lower than those in the control group(P<0.05).Before treatment,RSI and RFS scores of two groups were not significant(P>0.05).At 7 d after treatment,RSI and RFS scores of the observation group were lower than those of the control group(P<0.05).Conclusion Qingre Sanjie Capsule combined with Kaihoujian Spray can improve the clinical efficacy,reduce the symptom scores,improve the level of pepsin,reduce the levels of inflammatory factors and improve the symptoms and signs of reflux of patients with reflux pharyngitis,worthy of clinical promotion.
作者
章誉耀
孟易禹
吴珏婷
ZHANG Yuyao;MENG Yiyu;WU Jueting(Lishui People′s Hospital,Lishui 323000,Zhejiang,China)
出处
《辽宁中医杂志》
CAS
北大核心
2024年第9期102-104,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
清热散结胶囊
开喉剑喷雾剂
反流性咽喉炎
声嘶症状
Qingre Sanjie Capsule(清热散结胶囊)
Kaihoujian Spray(开喉剑喷雾剂)
reflux pharyngolaryngitis
symptoms of hoarseness
