摘要
目的:基于当代医案文献,采用数据挖掘方法分析中药治疗神经性皮炎的用药规律。方法:以山东中医药大学图书馆馆藏当代名老中医医案文献、中国知网、维普、万方数据库医案文献为数据来源,检索中药治疗神经性皮炎的医案并建立数据库,通过SPSS Statistics 26.0和SPSS Modeler 18.0软件对神经性皮炎病症特点和用药规律进行分析。结果:根据纳入和排除标准,获得医案文献130条。分析发现神经性皮炎好发于20~39岁的青壮年,女性患者集中于30~49岁,男性患者集中于20~39岁,男性患者多于女性患者。该病以皮疹瘙痒、皮肤增厚、皮肤苔藓等为主要临床症状,症状表现主要集中于皮肤损伤、情志异常、病久阴伤等方面。常见舌红,苔薄白或苔薄黄,脉弦。该病血虚风燥证多用当归、地黄、甘草、蒺藜、川芎等药,常用药对有川芎-白芍、川芎-甘草、熟地黄-防风等,基础方为四物汤和当归饮子;肌肤失养证多用地黄、苦参、白芍、蒺藜、白鲜皮等药,常用药对有首乌藤-苦参、首乌藤-白鲜皮、丹参-白芍等,基础方为荆芥四物汤和白鲜皮饮;肝郁化火证多用地黄、龙胆、栀子、柴胡、黄芩等药,常用药对有龙胆-首乌藤、首乌藤-栀子、龙胆-防风等,基础方为龙胆泻肝汤和丹栀逍遥散。结论:该研究对神经性皮炎的病症认识作出了补充,明确了治则治法及用药规律,研究结果为临床治疗和辨证用药提供了理论依据。
Objective:To mine the medication patterns of Chinese medicines for neurodermatitis based on contemporary medical cases in published articles.Method:The medical cases of treating neurodermatitis with Chinese medicines were retrieved from the medical case articles published by contemporary famous and old Chinese medicine doctors in the library of Shandong University of Traditional Chinese Medicine,CNKI,VIP,and Wanfang Data.A case library was established,and SPSS Statistics 26.0 and SPSS Modeler 18.0 were employed to analyze the symptoms and syndromes of neurodermatitis and mine the medication patterns.Result:According to the inclusion and exclusion criteria,130 medical case articles were included in this study.Neurodermatitis was prevalent in young adults between 20 and 39 years old(female patients of 30-49 years old and male patients of 20-39 years old),and male patients were more than female patients.The patients mainly presented the clinical manifestations of itchy rashes,thickened skin,and lichenification.Symptoms included skin injury,emotional abnormalities,and Yin damage caused by prolonged illness.Red tongue,thin white or yellow tongue coating,and wiry pulse were common in the patients.The patients with the syndrome of blood deficiency and wind dryness were often treated with Angelicae Sinensis Radix,Rehmanniae Radix,Glycyrrhizae Radix et Rhizoma,Tribuli Fructus,and Chuanxiong Rhizoma.The commonly used herb pairs included Chuanxiong Rhizoma-Paeoniae Radix Alba,Chuanxiong Rhizoma-Glycyrrhizae Radix et Rhizoma,and Rehmanniae Radix Praeparata-Saposhnikoviae Radix,and the commonly used prescriptions were Siwutang and Dangguiyinzi.The patients with the syndrome of muscle and skin dystrophy were mainly treated with Rehmanniae Radix,Sophorae Flavescentis Radix,Paeoniae Radix Alba,Tribuli Fructus,and Dictamni Cortex.The commonly used herb pairs included Polygoni Multiflori Caulis-Sophorae Flavescentis Radix,Polygoni Multiflori Caulis-Dictamni Cortex,and Salviae Miltiorrhizae Radix et Rhizoma-Paeoniae Radix Alba,and
作者
陈曙光
王学敏
段方红
陈乐乐
滕佳林
CHEN Shuguang;WANG Xuemin;DUAN Fanghong;CHEN Lele;TENG Jialin(Binzhou Hospital of Traditional Chinese Medicine(TCM)/Affiliated Chinese Medicine Hospital of Binzhou Medical College,Binzhou 256600,China;Binzhou Medical University Hospital,Binzhou 256600,China;Jinan Changqing District People's Hospital,Jinan 250355,China;Shandong University of TCM,Jinan 250355,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第19期206-213,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
山东省中医药科技发展计划项目(2019-0042)。
关键词
神经性皮炎
医案
数据挖掘
用药规律
neurodermatitis
medical case
date mining
medication pattern
