摘要
严重的耐药性是免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)急需攻克的难题。目前为止,现代医学对此还没有很好的解决办法。中医药普遍具有毒性低、不良反应小、疗效显著的特点,与现代医学联合,在肿瘤治疗的各个方面都发挥着积极作用。因此,可以尝试从中医药领域寻找突破,提高ICIs的功效,达到增效减毒的目的。回顾了近年来对ICIs耐药性发生机制的最新研究,以及中医药对逆转其耐药性的突破性进展,并总结讨论,以期能够为中医药缓解ICIs耐药性方面研究提供帮助。
The resistance to immune checkpoint inhibitors(ICIs)presents a critical challenge that necessitates immediate at-tention.Currently,modern medicine lacks effective solutions for this issue.Traditional Chinese medicine(TCM),on the other hand,is known for its attributes of low toxicity,minimal side effects and notable therapeutic efficacy.When integrated with mod-ern medicine,TCM demonstrates a positive role across various aspects of tumor treatment.Consequently,exploring potential breakthroughs in the realm of TCM becomes a worthwhile pursuit to enhance the effectiveness of ICIs while minimizing their toxic-ity.This review article aimed to outline the recent advancements in understanding the mechanisms underlying ICIs resistance and highlighted the groundbreaking progress achieved by TCM in overcoming this resistance.Through comprehensive analysis and synthesis of the existing research,this review aimed to contribute valuable insights to TCM potential in mitigating resistance to ICIs.
作者
赵振宇
吴建春
张博
骆莹滨
徐力立
李雁
ZHAO Zhenyu;WU Jianchun;ZHANG Bo;LUO Yingbin;XU Lii;LI Yan(Municipal Chinese Medicine Hospital of Shanghai University of Chinese Medicine,Shanghai 200071,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第9期52-58,I0019,共8页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81973795)
上海市进一步加快中医药传承创新发展三年行动计划项目(ZY[2021-2023]-0211)
上海中医医院“未来计划”项目(WL-LXBB-2021001K,WL-HBQN-2021010K)。
关键词
中医药
免疫检查点抑制剂
耐药性
免疫
traditional Chinese medicine
immune checkpoint inhibitors
drug resistance
immunity
