摘要
目的分析连续性血液净化(Continuous Blood Purification,CBP)在重症脓毒症中的治疗效果。方法选取2022年5月至2024年5月德江县人民医院收治的80例重症脓毒症患者作为研究对象,采用随机数字法进行分组,对照组采用常规治疗,观察组在对照组基础上联合连续性血液净化,每组各40例。比较两组患者炎症因子水平、血流动力学指标、临床疗效。结果治疗前,两组患者C-反应蛋白(C-reactive Protein,CRP)、肿瘤坏死因子-α(Tumor Necrosis Factorα,TNF-α)、白细胞介素-10(Interleukin 10,IL-10)、心率(HeartRate,HR)、呼吸频率值(Respiratory Rate,RR)、平均动脉压(Mean ArteryPressure,MAP)均无显著差异(P>0.05)。治疗后,观察组CRP、TNF-α、IL-10水平显著低于对照组(P<0.001);观察组HR、RR低于对照组(P<0.001),MAP高于对照组(P<0.001)。观察组治疗总有效率为97.50%,显著高于对照的80.00%,差异有统计学意义(P=0.013)。结论对于重症脓毒症患者,连续性血液净化更有利于减轻机体炎症反应、改善内环境稳态,促进病情恢复。
Objective To analyze the therapeutic effects of Continuous Blood Purification(CBP)in patients with severe sepsis.Methods 80 patients with severe sepsis admitted to Dejiang County People's Hospital from May 2022 to May 2024 were selected and randomly divided into two groups using a software-generated random number method.The control group(n=40)received conventional treatment,while the observation group(n=40)received CBP in addition to the conventional treatment.Inflammatory markers,hemodynamic parameters,and clinical efficacy were compared between the two groups.Results Before treatment,there were no significant differences in levels of C-reactive protein(CRP),tumor necrosis factorα(TNF-α),interleukin 10(IL-10),heart rate(HR),respiratory rate(RR),and mean arterial pressure(MAP)between the two groups(P>0.05).After treatment,the levels of CRP,TNF-α,and IL-10 in the observation group were significantly lower than those in the control group(P<0.001).The observation group also had lower HR and RR and higher MAP compared to the control group(P<0.001).The overall efficacy rate in the observation group was 97.50%,significantly higher than that(80.00%)in the control group(P=0.013).Conclusion For patients with severe sepsis,Continuous Blood Purification is more effective in reducing the inflammatory response,improving h omeostasis,and promoting recovery.
作者
喻贡勇
YU Gongyong(Dejiang County People's Hospital,Dejiang 565200,China)
出处
《中华灾害救援医学》
2024年第7期824-826,共3页
Chinese Journal of Disaster Medicine
