摘要
The solid-liquid viscous system formed by high viscosity crystallization solution impacts the flow and separation performance.Therefore,it is very important to study the viscosity mechanism to improve viscosity and regulate crystallization,ensuring a seamless production process.Herein,the viscosity of crystallization solution was taken as the measurement parameter of caffeine as a model drug.We investigated the viscosity mechanism of caffeine crystallization solutions by combining experiment and simulation.The results indicated that the weak interactions between caffeine and water result in increased viscosity of the caffeine crystallization solutions.Moreover,caffeine crystals possess elongated needle-like shapes,featuring a substantial specific surface area.Additionally,there isπ-πstacking occurring between the(200)crystal face and(110)crystal face,effectively fostering coalescence of the crystals towards the radial side of the crystal along its elongated axis,resulting in a more viscous crystallization system.The results contribute to comprehending the viscosity mechanism of crystal systems and provide theoretical foundation to enhance engineering efficiency in crystallization.
基金
supported by National Natural Science Foundation of China(grant No.21878067).
