摘要
目的 分析载脂蛋白E(ApoE)基因多态性与老年人群认知功能障碍的相关性。方法 回顾性分析2020年1月至2022年6月武汉科技大学附属普仁医院收治的106例认知功能障碍老年患者临床资料为认知障碍组,另收集84例同期入院的老年健康体检者作为对照组,比较两组血清β淀粉样蛋白1-42(Aβ1-42)、Aβ1-40及微管相关蛋白Tau、磷酸化Tau181(pTau181)水平等基线资料、ApoE基因型及等位基因频率分布情况,并分析ApoE基因多态性与观察组认知功能障碍类型的关系。结果 认知障碍组简易精神状态评估量表(MMSE)评分及蒙特利尔认知评估量表(MoCA)评分低于对照组(P<0.05),血清Aβ1-42、Aβ1-40及Tau、p-Tau181水平高于对照组(P<0.05)。两组ApoE基因型及等位基因频率比较,差异具有统计学意义(P<0.05),Logistic回归分析校正混杂因素后,携带ε4等位基因者患认知功能障碍相对风险度(OR)=2.701,95%CI(1.239~5.861),P<0.05。认知障碍组中,痴呆者ApoE ε4等位基因频率明显高于轻度认知功能障碍者(P<0.05),Logistic回归分析校正混杂因素后,携带ε4等位基因者发生痴呆的OR=2.779,95%CI(1.475~5.234),P<0.05。结论 ApoE ε4等位基因可增加本地区老年人群认知功能障碍发生风险,对促进认知功能障碍进展也有积极作用。。
Objective The study aims to analyze the correlation between apolipoprotein E(ApoE)gene polymorphism and cognitive impairment in the elderly.Methods The clinical data of 106 elderly patients with cognitive impairment in Puren Hospital affiliated to Wuhan University of Science and Technology were retrospectively analyzed between January 2020 and June 2022 and the cases were selected as cognitive impairment group,and 84 elderly healthy subjects with physical examination during the same period were collected as the control group.The baseline data such as serumβamyloid 1-42(Aβ1-42),Aβ1-40 and microtubule-associated protein Tau,phosphorylated Tau181(p-Tau181),and ApoE genotype and al-lele frequency distribution were compared between the two groups.The relationship between ApoE gene polymorphism and the cognitive impairment type in the observation group was analyzed.Results The Mini-Mental State Evaluation(MMSE)score and Montreal Cogni-tive Assessment(MoCA)score of the cognitive impairment group were lower than those of the control group(P<0.05),while the levels of se-rum Aβ1-42,Aβ1-40,Tau and p-Tau181 were higher than those of the control group(P<0.05).The ApoE genotype and allele frequencies between the two groups were significantly different(P<0.05).Logistic regression analysis showed that after adjusting for confounding factors,the odds ratio(OR)of cognitive impairment in patients carryingε4 allele with 95%CI(1.239-5.861)was 2.701 and P<0.05.In cognitive impairment group,the frequency of ApoE 4 allele in the patients with dementia was significantly higher than that in the pa-tients with mild cognitive impairment(P<0.05).Logistic regression analysis revealed that after adjusting for confounding factors,the OR of dementia in the patients withε4 allele was 2.779 with 95%CI(1.475-5.234)and P<0.05.Conclusion ApoEε4 allele can in-crease the risk of cognitive impairment in the elderly population in this region,and also has a positive effect on promoting the progres-sion of cognitive impairment.
作者
柳军凡
严钢莉
吴磊
LIU Junfan;YAN Gangli;WU Lei(Department of Critical Care Medicine,Medical School of Wuhan University of Science and Technology,Wuhan 430065,Hubei,China;Department of Neurology,Puren Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430080,Hubei,China;Hubei Provincial Key Laboratory of Occupational Hazard Identification and Control,School of Labor Health and Environmental Health,School of Public Health,Wuhan University of Science and Technology,Wuhan University of Science and Technology,Wuhan 430065,Hubei,China)
出处
《医学研究与战创伤救治》
CAS
北大核心
2024年第6期588-592,共5页
Journal of Medical Research & Combat Trauma Care
基金
湖北省自然科学基金(2022CFB513)。
