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芪珍胶囊联合NP方案化疗对气虚血瘀兼瘀阻化热型非小细胞肺癌患者的治疗效果

Therapeutic effect of Qizhen capsule combined with NP chemotherapy regimen in non-small cell lung cancer patients with Qi deficiency and blood stasis and stasis-converting-to-heat syndrome
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摘要 目的探讨芪珍胶囊联合长春瑞滨+顺铂(NP)方案化疗对气虚血瘀兼瘀阻化热型非小细胞肺癌(NSCLC)患者的治疗效果。方法根据治疗方法的不同将82例气虚血瘀兼瘀阻化热型NSCLC患者分为对照组(n=41,NP方案化疗)和观察组(n=41,芪珍胶囊联合NP方案化疗)。比较观察组和对照组、不同病理类型及临床分期观察组患者的临床疗效。比较两组患者的生活质量和体重改善情况、气虚血瘀兼瘀阻化热症状改善情况、血常规指标[红细胞(RBC)、白细胞(WBC)、血小板计数(PLT)、血红蛋白(Hb)]及免疫功能指标(CD3^(+)、CD4^(+)、CD8^(+)水平及CD4^(+)/CD8^(+))。结果观察组患者的总有效率明显高于对照组,差异有统计学意义(P﹤0.01)。观察组中,鳞状细胞癌、腺癌、腺鳞癌患者的总有效率比较,差异无统计学意义(P﹥0.05)。观察组中,Ⅰ、Ⅱ、Ⅲ、Ⅳ期NSCLC患者的总有效率比较,差异有统计学意义(P﹤0.05)。治疗后,观察组患者的生活质量改善率明显高于对照组(P﹤0.01),两组患者体重改善率比较,差异无统计学意义(P﹥0.05)。治疗后,观察组患者气虚血瘀兼瘀阻化热各症状改善率均高于对照组(P﹤0.05)。治疗后,观察组患者WBC、PLT、CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)均高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P﹤0.05)。结论芪珍胶囊联合NP方案化疗不仅可提高气虚血瘀兼瘀阻化热型NSCLC患者的临床疗效和生活质量,还可改善患者的症状、血常规指标及免疫功能。 Objective To investigate the therapeutic effect of Qizhen capsule combined with vinorelbine+cisplatin(NP)chemotherapy regimen in non-small cell lung cancer(NSCLC)patients with Qi deficiency and blood stasis and stasis-converting-to-heat syndrome.Method A total of 82 NSCLC patients with Qi deficiency and blood stasis and stasisconverting-to-heat syndrome were divided into control group(n=41,NP regimen chemotherapy)and observation group(n=41,Qizhen capsule combined with NP regimen chemotherapy)according to different treatment methods.The clinical efficacy of observation group and control group,patients with different pathological types and clinical stages in observation group were compared.The improvement of quality of life,body weight and symptoms of Qi deficiency and blood stasis and stasis-converting-to-heat syndrome,blood routine indexes[red blood cell(RBC),white blood cell(WBC),platelet(PLT),hemoglobin(Hb)]and immune function indexes(CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+))were compared between the two groups.Result The total effective rate in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.01).In the observation group,there was no statistically significant difference in total effective rate of patients with squamous cell carcinoma,adenocarcinoma,and adenosquamous carcinoma(P>0.05).In the observation group,there was significantly difference in total effective rate of patients with stage I,II,III,and IV NSCLC(P<0.05).After treatment,the improvement rate of quality of life in observation group was significantly higher than that in control group(P<0.01),and there was no significant difference in the weight improvement rate between the two groups(P>0.05).After treatment,the improvement rates of symptoms of Qi deficiency and blood stasis and stasis-converting-to-heat symptoms in observation group were higher than those in control group(P<0.05).After treatment,the levels of WBC,PLT,CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in observation
作者 关素珍 尹金磊 白方会 李长生 付玉娟 GUAN Suzhen;YIN Jinlei;BAI Fanghui;LI Changsheng;FU Yujuan(Department of Traditional Chinese Medicine,Nanyang Central Hospital,Nanyang 473000,He’nan,China;Department of Scientific Research,Nanyang Central Hospital,Nanyang 473000,He’nan,China;Department of Medical Oncology,Nanyang Central Hospital,Nanyang 473000,He’nan,China;Nuclear Medicine Radiology and Immunology Room,Nanyang Central Hospital,Nanyang 473000,He’nan,China)
出处 《癌症进展》 2024年第14期1527-1531,1561,共6页 Oncology Progress
基金 南阳市科技发展计划项目(KJGG093)。
关键词 芪珍胶囊 气虚血瘀 瘀阻化热 非小细胞肺癌 化疗 疗效 Qizhen capsule Qi deficiency and blood stasis stasis-converting-to-heat non-small cell lung cancer chemotherapy efficacy
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