摘要
目的分析无创高频通气(non invasive high-frequency ventilation,NHFV)结合咖啡因在新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)撤机中的应用价值。方法随机选取2021年1月—2023年12月安溪县医院新生儿科收治的100例NRDS患儿为研究对象,根据不同治疗方法将其分为两组,各50例,对照组撤机后采用经鼻持续正压通气(nasal continuous positive airway pressure,NCPAP)联合咖啡因治疗,研究组撤机后采用NHFV结合咖啡因治疗,比较两组撤机成功率、撤机后情况、血气分析指标。结果研究组撤机成功率为98.00%(49/50),高于对照组的86.00%(43/50),差异有统计学意义(χ^(2)=4.891,P=0.027)。研究组72 h内呼吸暂停次数少于对照组,用氧时间、通气时间、住院时间短于对照组,差异有统计学意义(P均<0.05);机械通气撤离后1 h和12 h,两组的pH值比较,差异无统计学意义(P均>0.05);撤机后1、12 h,研究组的动脉氧分压高于对照组,动脉血二氧化碳分压低于对照组,差异有统计学意义(P均<0.05)。结论NHFV结合咖啡因在NRDS撤机中的应用有助于提高撤机成功率,并且能够改善呼吸功能、减少通气时间和住院时间,不影响患者的酸碱平衡。
Objective To analyze the application value of non-invasive high-frequency ventilation(NHFV)combined with caffeine in weaning of neonatal respiratory distress syndrome(NRDS).Methods A total of 100 children with NRDS admitted to the Department of Neonatology,Anxi County Hospital from January 2021 to December 2023 were randomly selected as the research objects.They were divided into two groups by different treatment methods,with 50 cases in each group.The control group was treated with nasal continuous positive airway pressure(NCPAP)combined with caffeine after weaning.The study group was treated with NHFV combined with caffeine after weaning.The success rate of weaning,the situation after weaning and blood gas analysis indexes were compared between the two groups.Results The success rate of weaning in the study group was 98.00%(49/50),which was higher than 86.00%(43/50)in the control group,and the difference was statistically significant(χ^(2)=4.891,P=0.027).The number of apneas within 72 hours in the study group was less than that in the control group,and the oxygen time,ventilation time and hospitalization time were shorter than those in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in pH value between the two groups at 1 h and 12 h after mechanical ventilation withdrawal(both P>0.05);at 1 hour and 12 hours after weaning,the arterial oxygen partial pressure in the study group was higher than that in the control group,and the arterial carbon dioxide partial pressure was lower than that in the control group,the differences were statistically significant(both P<0.05).Conclusion The application of NHFV combined with caffeine in NRDS weaning is helpful to improve the success rate of weaning,and can improve respiratory function,reduce ventilation time and hospitalization time,without affecting the acid-base balance of patients.
作者
肖建佳
XIAO Jianjia(Neonatology Department,Anxi County Hospital,Quanzhou 362400,Fujian,China)
出处
《中外医疗》
2024年第21期57-60,共4页
China & Foreign Medical Treatment
关键词
撤机
无创高频通气
新生儿呼吸窘迫综合征
应用价值
咖啡因
Withdrawal of mechanical ventilation
Non invasive high-frequency ventilation
Neonatal respiratory distress syndrome
Application value
Caffeine
