摘要
目的比较单孔胸腔镜下肺段、肺叶切除术治疗早期非小细胞肺癌患者的效果、并发症发生率。方法回顾性分析2021年9月至2023年3月常州市肿瘤医院收治的78例早期非小细胞肺癌患者的临床资料,根据治疗方案不同分为参照组和研究组,每组各39例。参照组开展单孔胸腔镜下肺叶切除术治疗,研究组开展单孔胸腔镜下肺段切除术治疗。比较两组患者的手术开展情况、并发症发生率及肺功能、肿瘤标志物指标。结果两组患者的手术时间比较,差异无统计学意义(P>0.05)。研究组的胸腔引流量、术中出血量少于参照组,住院时间短于参照组,并发症总发生率低于参照组,术后1个月时的第1秒用力呼气量占预计值百分比(FEV1%)、用力肺活量占预计值的百分比(FVC%)、最大自主通气量占预计值的百分比(MVV%)、深吸气量(IC)、FEV1/FVC等指标高于参照组,糖类抗原50(CA50)、癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)等指标低于参照组,差异有统计学意义(P<0.05)。结论相较于单孔胸腔镜下肺叶切除术,对早期非小细胞肺癌患者开展单孔胸腔镜下肺段切除术治疗,治疗效果更佳,术后并发症发生率更低,且术后肺功能改善更为明显,效果显著。
Objective To compare the efficacy and complication rate of single-aperture thoracoscopic segmental and lobectomy in the treatment of early non-small cell lung cancer.Methods The clinical data of 78 patients with early non-small cell lung cancer admitted to Changzhou Cancer Hospital from September 2021 to March 2023 were retrospectively analyzed,and they were divided into reference group and study group according to different treatment plans,with 39 cases in each group.The reference group was treated with single-aperture thoracoscopic lobectomy,while the study group was treated with single-aperture thoracoscopic segmental resection.The operation,complication rate,lung function and tumor markers were compared between the two groups.Results There was no significant difference in operation time between the two groups(P>0.05).The thoracic drainage volume and intraoperative blood loss of the study group were less than those of the reference group,the length of hospital stay was shorter,and the total complication rate was lower than that of the reference group,the percentage of forced expiratory volume in first second to the predicted value(FEV1%),the percentage of forced vital capacity in the predicted value(FVC%),the percentage of maximal voluntary ventilation in the predicted value(MVV%),inspiratory capacity(IC),FEV1/FVC and other indexes one month after surgery were higher than those in the reference group,the indexes of carbohydrate antigen 50(CA50),carcinoembryonic antigen(CEA)and cytokeratin-19-fragment(CYFRA21-1)were lower than those of the reference group,and the differences were statistically significant(P<0.05).Conclusion Compared with single-aperture thoracoscopic lobectomy,single-aperture thoracoscopic segmental resection for patients with early non-small cell lung cancer has better therapeutic effect,lower incidence of postoperative complications,and more significant improvement in postoperative lung function.
作者
卫锐狮
冯利
赵士磊
顾春东
WEI Ruishi;FENG Li;ZHAO Shilei;GU Chundong(Department of Thoracic Surgery,Changzhou Cancer Hospital,Changzhou Fourth People's Hospital,Jiangsu Province,Changzhou 213002,China;Department of Thoracic Surgery,the First Affiliated Hospital of Dalian Medical University,Liaoning Province,Dalian 116000,China)
出处
《中国当代医药》
CAS
2024年第24期52-55,共4页
China Modern Medicine
基金
江苏省常州市卫生健康青苗人才培养工程项目(CZQM2022019)
江苏省常州市“龙城医星”卫生青年科技人才托举工程项目(CYF2022007)。
关键词
单孔胸腔镜下肺段切除术
肺叶切除术
早期非小细胞肺癌
并发症发生率
肺功能
Single-aperture thoracoscopic segmental
Pulmonary lobectomy
Early non-small cell lung cancer
Incidence of complications
Pulmonary function
